低体重指数癫痫患者的吡仑帕奈过量：一例病例报告及文献综述
Perampanel overdose in low body mass index patients with epilepsy: a case report and review of the literature.
作者信息
Phabphal Kanitpong, Koonalintip Prut
机构信息
Neurology Unit, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand.
出版信息
J Med Case Rep. 2021 Mar 29;15(1):147. doi: 10.1186/s13256-021-02759-9.
BACKGROUND
Perampanel (PER) is a novel antiepileptic drug (AED) which employs a completely different mechanism of action compared to existing medications. Overall, PER is considered to be safe up to a dose of 12 mg per day. When used to treat refractory and super-refractory status epilepticus, PER seems to be extremely well tolerated; this is true even when used at doses of up to 32 mg. There are currently only three case reports on the effects of acute PER overdose in epilepsy patients.
CASE PRESENTATION
We report a 16-year-old Thai woman with a low body weight, who took PER at a dose of 40 times that of the prescribed daily dose. She experienced only an alteration of consciousness, without any systemic medical effects, and made a full recovery within 3 days without gastric lavage or specific treatment.
CONCLUSION
Our report demonstrates that an acute PER overdose may not produce serious adverse systemic effects. Individuals with adverse central nervous system (CNS) effects, such as altered consciousness, can experience a rapid recovery.
背景
吡仑帕奈（PER）是一种新型抗癫痫药物（AED），其作用机制与现有药物完全不同。总体而言，PER在每日剂量达12毫克时被认为是安全的。当用于治疗难治性和超难治性癫痫持续状态时，PER似乎耐受性极佳；即使在高达32毫克的剂量下使用也是如此。目前仅有三篇关于癫痫患者急性PER过量影响的病例报告。
病例介绍
我们报告一名体重较轻的16岁泰国女性，她服用的PER剂量是规定日剂量的40倍。她仅出现意识改变，无任何全身医学影响，未进行洗胃或特殊治疗，3天内完全康复。
结论
我们的报告表明，急性PER过量可能不会产生严重的全身不良影响。出现意识改变等中枢神经系统（CNS）不良影响的个体可迅速康复。
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