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超越社交记忆的 CA2:在海马体信息处理中起基本作用的证据。

CA2 beyond social memory: Evidence for a fundamental role in hippocampal information processing.

机构信息

Department of Computational Neuroscience, University of Göttingen, Germany; Bernstein Center for Computational Neuroscience, University of Göttingen, Germany; Department of Computational Physiology, Simula Research Laboratory, Lysaker, Norway; Centre for Integrative Neuroplasticity, University of Oslo, Norway.

Department of Computational Science and Technology, KTH Royal Institute of Technology, Sweden.

出版信息

Neurosci Biobehav Rev. 2021 Jul;126:398-412. doi: 10.1016/j.neubiorev.2021.03.020. Epub 2021 Mar 26.

Abstract

Hippocampal region CA2 has received increased attention due to its importance in social recognition memory. While its specific function remains to be identified, there are indications that CA2 plays a major role in a variety of situations, widely extending beyond social memory. In this targeted review, we highlight lines of research which have begun to converge on a more fundamental role for CA2 in hippocampus-dependent memory processing. We discuss recent proposals that speak to the computations CA2 may perform within the hippocampal circuit.

摘要

由于在社会识别记忆中的重要性,海马区 CA2 受到了越来越多的关注。虽然其具体功能仍有待确定,但有迹象表明 CA2 在各种情况下都起着重要作用,其作用范围远远超出了社会记忆。在本次有针对性的综述中,我们重点介绍了一些研究方向,这些研究方向开始集中探讨 CA2 在海马体依赖型记忆处理中的更基本作用。我们讨论了最近的一些观点,这些观点涉及 CA2 在海马体回路中可能进行的计算。

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