青少年肾上腺皮质癌延迟诊断，最初被误诊为多囊卵巢综合征。
Delayed Identification of Adolescent Adrenal Cortical Carcinoma Initially Diagnosed as Polycystic Ovary Syndrome.
机构信息
Department of Endocrinology, Capital Institute of Pediatrics, Beijing, China.
Department of Thoracic Surgery, Capital Institute of Pediatrics, Beijing, China.
出版信息
J Pediatr Adolesc Gynecol. 2021 Oct;34(5):764-767. doi: 10.1016/j.jpag.2021.03.004. Epub 2021 Mar 26.
BACKGROUND
Adrenocortical carcinoma is a rare, isolated malignancy.
CASE
A 13-year-old girl presented with secondary amenorrhea, hirsutism, and hypertension. Her clinical manifestations were interpreted as polycystic ovary syndrome and hyperinsulinemia. The rapid progression of this pubertal girl's virilization should have, but did not draw clinical attention to her malignancy. Because her condition worsened, she ultimately was transferred to our hospital because of an abdominal mass. She was diagnosed with a very large adrenal cortical carcinoma with pulmonary metastasis. The child was in the advanced stage and presented adrenal crisis after chemotherapy and mitotane treatment.
SUMMARY AND CONCLUSION
Rapidly progressive masculinization, with a marked increase in adrenal-derived androgens, might indicate rare adrenal neoplasms.
背景
肾上腺皮质癌是一种罕见的孤立性恶性肿瘤。
病例报告
一名 13 岁女孩因继发性闭经、多毛症和高血压就诊。其临床表现被解读为多囊卵巢综合征和高胰岛素血症。这个青春期女孩的男性化迅速进展，但并未引起临床对其恶性肿瘤的重视。由于病情恶化，她最终因腹部肿块转入我院。她被诊断为巨大肾上腺皮质癌伴肺转移。患儿处于晚期，在化疗和米托坦治疗后出现肾上腺危象。
总结和结论
快速进展的男性化，伴有明显增加的肾上腺源性雄激素，可能提示罕见的肾上腺肿瘤。
Zotero 插件