老年患者的慢性茶碱中毒合并急性中毒

Acute on Chronic Theophylline Toxicity in an Elderly Patient.

作者信息

Kong Alexander, Ghosh Somshukla, Guan Chelsea, Fries Brittany L, Burke Floyd W

机构信息

Internal Medicine Residency, University of Central Florida-HCA Healthcare Graduate Medical Education (GME), Orlando, USA.

Internal Medicine, University of Central Florida College of Medicine, Orlando, USA.

出版信息

Cureus. 2021 Feb 22;13(2):e13484. doi: 10.7759/cureus.13484.

DOI:10.7759/cureus.13484

PMID:33777571

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7990022/

Abstract

Theophylline toxicity has become rare in the 21st century, as the drug has fallen out of favor due to serious life-threatening adverse events, narrow therapeutic window and readily available therapeutic alternatives. The wide array of clinical symptoms related to theophylline toxicity makes this diagnosis challenging for the treating physician. We report a case of an elderly gentleman who presented with respiratory failure and seizures due to severe theophylline toxicity.

摘要

在21世纪，由于严重的危及生命的不良事件、狭窄的治疗窗以及易于获得的治疗替代方案，茶碱中毒已变得罕见。与茶碱中毒相关的一系列临床症状使得治疗医生难以做出诊断。我们报告一例老年男性因严重茶碱中毒出现呼吸衰竭和癫痫发作的病例。