用于胶质瘤的循环肿瘤细胞
Circulating Tumor Cells for Glioma.
作者信息
Zhang Huikai, Yuan Fanen, Qi Yangzhi, Liu Baohui, Chen Qianxue
机构信息
Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, China.
出版信息
Front Oncol. 2021 Mar 10;11:607150. doi: 10.3389/fonc.2021.607150. eCollection 2021.
Abstract
Liquid biopsy has entered clinical applications for several cancers, including metastatic breast, prostate, and colorectal cancer for CTC enumeration and NSCLC for EGFR mutations in ctDNA, and has improved the individualized treatment of many cancers, but relatively little progress has been made in validating circulating biomarkers for brain malignancies. So far, data on circulating tumor cells about glioma are limited, the application of circulating tumor cells as biomarker for glioma patients has only just begun. This article reviews the research status and application prospects of circulating tumor cells in gliomas. Several detection methods and research results of circulating tumor cells about clinical research in gliomas are briefly discussed. The wide application prospect of circulating tumor cells in glioma deserves further exploration, and the research on more sensitive and convenient detection methods is necessary.
摘要
液体活检已应用于多种癌症的临床实践，包括用于循环肿瘤细胞（CTC）计数的转移性乳腺癌、前列腺癌和结直肠癌，以及用于检测循环肿瘤DNA（ctDNA）中表皮生长因子受体（EGFR）突变的非小细胞肺癌（NSCLC），并改善了多种癌症的个体化治疗，但在验证脑恶性肿瘤的循环生物标志物方面进展相对较小。到目前为止，关于胶质瘤循环肿瘤细胞的数据有限，将循环肿瘤细胞作为胶质瘤患者生物标志物的应用才刚刚开始。本文综述了循环肿瘤细胞在胶质瘤中的研究现状和应用前景。简要讨论了胶质瘤临床研究中循环肿瘤细胞的几种检测方法和研究结果。循环肿瘤细胞在胶质瘤中的广泛应用前景值得进一步探索，开展更灵敏、便捷检测方法的研究很有必要。
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本文引用的文献
1
[Cerebellar Glioblastoma with Intrathecal Dissemination:A Report of Four Cases].[伴有鞘内播散的小脑胶质母细胞瘤：4例报告]
No Shinkei Geka. 2020 Mar;48(3):237-244. doi: 10.11477/mf.1436204169.
2
Association between Postoperative Detection of Circulating Tumor Cells and Recurrence in Patients with Prostate Cancer.循环肿瘤细胞检测与前列腺癌患者术后复发的相关性。
J Urol. 2020 Jun;203(6):1128-1134. doi: 10.1097/JU.0000000000000704. Epub 2019 Dec 17.
3
Efficient separation of tumor cells from untreated whole blood using a novel multistage hydrodynamic focusing microfluidics.使用新型多级流体动力学聚焦微流控技术从未经处理的全血中高效分离肿瘤细胞。
Talanta. 2020 Jan 15;207:120261. doi: 10.1016/j.talanta.2019.120261. Epub 2019 Aug 14.
4
Clonality of circulating tumor cells in breast cancer brain metastasis patients.乳腺癌脑转移患者循环肿瘤细胞的克隆性。
Breast Cancer Res. 2019 Sep 3;21(1):101. doi: 10.1186/s13058-019-1184-2.
5
Capture and Detection of Circulating Glioma Cells Using the Recombinant VAR2CSA Malaria Protein.利用重组 VAR2CSA 疟原蛋白捕获和检测循环脑肿瘤细胞
Cells. 2019 Aug 28;8(9):998. doi: 10.3390/cells8090998.
6
Significance of liquid biopsy in glioblastoma - A review.液体活检在胶质母细胞瘤中的意义——综述。
J Biotechnol. 2019 Jun 10;298:82-87. doi: 10.1016/j.jbiotec.2019.04.011. Epub 2019 Apr 12.
7
Frequency of Circulating Tumor Cells (CTC) in Patients with Brain Metastases: Implications as a Risk Assessment Marker in Oligo-Metastatic Disease.脑转移患者循环肿瘤细胞（CTC）的频率：作为寡转移疾病风险评估标志物的意义。
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8
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Neuro Oncol. 2018 Oct 1;20(suppl_4):iv1-iv86. doi: 10.1093/neuonc/noy131.
9
Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods.估算 2018 年全球癌症发病率和死亡率：GLOBOCAN 来源和方法。
Int J Cancer. 2019 Apr 15;144(8):1941-1953. doi: 10.1002/ijc.31937. Epub 2018 Dec 6.
10
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Cancer Res. 2018 Dec 1;78(23):6632-6642. doi: 10.1158/0008-5472.CAN-18-0650. Epub 2018 Oct 15.
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