氮芥对鸟嘌呤-N7 位点进行 DNA 序列选择性烷基化的机制。 - Suppr

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超能文献

Mechanisms of DNA sequence selective alkylation of guanine-N7 positions by nitrogen mustards.

作者信息

Kohn K W, Hartley J A, Mattes W B

机构信息

Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, Maryland.

出版信息

Biochem Pharmacol. 1988 May 1;37(9):1799-800. doi: 10.1016/0006-2952(88)90452-2.

DOI:10.1016/0006-2952(88)90452-2

PMID:3377838

Abstract

摘要

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Mechanisms of DNA sequence selective alkylation of guanine-N7 positions by nitrogen mustards.氮芥对鸟嘌呤-N7 位点进行 DNA 序列选择性烷基化的机制。

Biochem Pharmacol. 1988 May 1;37(9):1799-800. doi: 10.1016/0006-2952(88)90452-2.

Mechanisms of DNA sequence selective alkylation of guanine-N7 positions by nitrogen mustards.氮芥对鸟嘌呤-N7 位进行 DNA 序列选择性烷基化的机制。

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DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards.氮芥对鸟嘌呤-N7的烷基化作用的DNA序列选择性

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Effect of ionic strength and cationic DNA affinity binders on the DNA sequence selective alkylation of guanine N7-positions by nitrogen mustards.离子强度和阳离子DNA亲和结合剂对氮芥对鸟嘌呤N7位的DNA序列选择性烷基化的影响。

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DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards is preserved in intact cells.氮芥对鸟嘌呤 - N7 的烷基化作用的 DNA 序列选择性在完整细胞中得以保留。

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Sequence specificity of alkylation for a series of nitrogen mustard-containing analogues of distamycin of increasing binding site size: evidence for increased cytotoxicity with enhanced sequence specificity.一系列结合位点大小不断增加的偏端霉素含氮芥类似物的烷基化序列特异性：序列特异性增强导致细胞毒性增加的证据

Biochemistry. 1995 Oct 10;34(40):13034-41. doi: 10.1021/bi00040a014.

Synthesis and DNA-sequence selectivity of a series of mono- and difunctional 9-aminoacridine nitrogen mustards.一系列单官能和双官能9-氨基吖啶氮芥的合成及其DNA序列选择性

J Med Chem. 1994 Jan 7;37(1):67-72. doi: 10.1021/jm00027a008.

Ab initio study of alkylation of guanine-cytosine base pair by sulfur and nitrogen mustards.从头算研究硫芥和氮芥对鸟嘌呤-胞嘧啶碱基对的烷基化作用。

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The sequence specificity of alkylation for a series of benzoic acid mustard and imidazole-containing distamycin analogues: the importance of local sequence conformation.一系列苯甲酸氮芥和含咪唑的双螺旋霉素类似物的烷基化序列特异性：局部序列构象的重要性。

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DNA-directed alkylating ligands as potential antitumor agents: sequence specificity of alkylation by intercalating aniline mustards.作为潜在抗肿瘤剂的DNA定向烷基化配体：嵌入型苯胺氮芥烷基化的序列特异性

Biochemistry. 1990 Oct 23;29(42):9799-807. doi: 10.1021/bi00494a007.

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