先天性矫正型大动脉转位成人右心室重构的特征追踪MRI分形分析
Feature-Tracking MRI Fractal Analysis of Right Ventricular Remodeling in Adults with Congenitally Corrected Transposition of the Great Arteries.
作者信息
Kawakubo Masateru, Nagao Michinobu, Ishizaki Umiko, Shiina Yumi, Inai Kei, Yamasaki Yuzo, Yoneyama Masami, Sakai Shuji
机构信息
Department of Health Sciences, Faculty of Medical Sciences (M.K.), and Department of Clinical Radiology, Graduate School of Medical Sciences (Y.Y.), Kyushu University, Fukuoka, Japan; Department of Diagnostic Imaging and Nuclear Medicine (M.N., U.I., S.S.) and Department of Pediatric Cardiology and Adult Congenital Cardiology (Y.S., K.I.), Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, Japan; and Philips Japan, Tokyo, Japan (M.Y.).
出版信息
Radiol Cardiothorac Imaging. 2019 Oct 31;1(4):e190026. doi: 10.1148/ryct.2019190026. eCollection 2019 Oct.
PURPOSE
To assess a recently available technique for quantification of right ventricular (RV) trabeculae that is based on fractal analysis performed by using cardiac MRI feature tracking, in patients with congenitally corrected transposition of the great arteries (cc-TGA).
MATERIALS AND METHODS
A total of 19 patients (eight men, 11 women; mean age, 35 years ± 10 [standard deviation]) with consecutive cc-TGA who underwent cardiac MRI were enrolled in the study. For analysis, patients were divided into two groups: six patients (four men, two women; mean age, 34 years ± 14) with an end-systolic RV volume index higher than 72 mL/m (indicative of adverse RV remodeling) and 13 patients (four men, nine women; mean age, 36 years ± 9) in whom this index was lower than or equal to 72 mL/m (indicative of adapted RV). The following outcomes were quantified in the midsection of the RV: fractional fractal dimension (FD) and diastolic FD, circumferential strain, and radial strain. Receiver operating characteristic (ROC) analysis was performed to determine the cutoff FD values for the detection of adverse RV remodeling. Correlations among fractional FD, diastolic FD, circumferential strain, and radial strain were calculated by using Pearson correlation coefficient () analysis.
RESULTS
The following ROC values were identified for fractional and diastolic FD: cutoff, 0.09 and 1.39, respectively; area under the ROC curve, 0.95 and 0.68, respectively; sensitivity, 1.00 and 0.33, respectively; and specificity, 0.92 and 1.00, respectively. Fractional FD correlated with circumferential strain and radial strain ( = -0.70 and 0.69, respectively; < .01), as did diastolic FD ( = 0.37 and -0.38, respectively; < .05).
CONCLUSION
The fractional FD derived from cardiac MRI feature-tracking analysis correlates with adverse RV remodeling, including a changed strain pattern and trabeculae, in patients with cc-TGA.© RSNA, 2019.
目的
评估一种最近可用的基于心脏磁共振成像特征追踪进行分形分析的定量右心室小梁的技术，用于大动脉转位矫正术（cc-TGA）患者。
材料与方法
本研究纳入了19例连续接受心脏磁共振成像的cc-TGA患者（8例男性，11例女性；平均年龄35岁±10[标准差]）。为进行分析，患者被分为两组：6例患者（4例男性，2例女性；平均年龄34岁±14），其收缩末期右心室容积指数高于72 mL/m²（提示右心室不良重塑）；13例患者（4例男性，9例女性；平均年龄36岁±9），该指数低于或等于72 mL/m²（提示右心室适应性改变）。对右心室中部的以下指标进行定量：分数维分形维数（FD）和舒张期FD、圆周应变和径向应变。进行受试者操作特征（ROC）分析以确定检测右心室不良重塑的临界FD值。使用Pearson相关系数（）分析计算分数FD、舒张期FD、圆周应变和径向应变之间的相关性。
结果
分数FD和舒张期FD的ROC值如下：临界值分别为0.09和1.39；ROC曲线下面积分别为0.95和0.68；敏感性分别为1.00和0.33；特异性分别为0.92和1.00。分数FD与圆周应变和径向应变相关（分别为 = -0.70和0.69；<0.01），舒张期FD也是如此（分别为 = 0.37和 -0.38；<0.05）。
结论
在cc-TGA患者中，源自心脏磁共振成像特征追踪分析的分数FD与右心室不良重塑相关，包括应变模式和小梁的改变。©RSNA，2019。
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