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骨折相关感染(FRI)的预防、诊断和治疗的当前概念。

Current concepts in the prevention, diagnosis and treatment of fracture-related infection (FRI).

机构信息

The Royal London Limb Reconstruction Service, Royal London Hospital, Barts Health NHS Trust, London, UK.

Department of Trauma & Orthopaedic Surgery, St George's University Hospitals NHS Foundation Trust, London, UK.

出版信息

Eur J Orthop Surg Traumatol. 2021 Jul;31(5):957-966. doi: 10.1007/s00590-021-02956-8. Epub 2021 Mar 29.

DOI:10.1007/s00590-021-02956-8
PMID:33778904
Abstract

Fracture-related infection (FRI) is one of the most challenging complications following operative management of fractures. It can have profound implications for the patient, can be associated with considerable morbidity and often lead to impaired outcomes. There are significant healthcare-related costs. In recent years, there has been significant progress towards developing preventative strategies. Furthermore, diagnostic algorithms and management protocols have recently been reported. Lack of a strong evidence base has previously hindered efforts to implement these and develop established standards of care. There are multiple aspects of care that need to be considered and a multi-disciplinary approach is recommended. In this narrative review, we present the most up-to-date recommendations in the prevention, diagnosis and management of FRI.

摘要

骨折相关感染(FRI)是骨折术后管理中最具挑战性的并发症之一。它可能对患者产生深远影响,与相当大的发病率相关,并经常导致预后受损。存在重大的与医疗保健相关的成本。近年来,在开发预防策略方面取得了重大进展。此外,最近还报告了诊断算法和管理方案。以前,缺乏强有力的证据基础一直阻碍了实施这些措施和制定既定护理标准的努力。需要考虑多个护理方面,建议采用多学科方法。在这篇叙述性综述中,我们提出了 FRI 的预防、诊断和管理方面的最新建议。

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Arch Orthop Trauma Surg. 2021 Jul;141(7):1215-1230. doi: 10.1007/s00402-020-03525-0. Epub 2020 Aug 29.
2
The economic burden of infections following intramedullary nailing for a tibial shaft fracture in England.英格兰胫骨干骨折髓内钉固定术后感染的经济负担。
BMJ Open. 2020 Aug 26;10(8):e035404. doi: 10.1136/bmjopen-2019-035404.
3
Diagnosing Fracture-Related Infection: Current Concepts and Recommendations.
2023 年 WSES 老年和虚弱患者创伤管理指南。
World J Emerg Surg. 2024 May 31;19(1):18. doi: 10.1186/s13017-024-00537-8.
4
Implants coating strategies for antibacterial treatment in fracture and defect models: A systematic review of animal studies.骨折与缺损模型中用于抗菌治疗的植入物涂层策略:动物研究的系统评价
J Orthop Translat. 2024 Mar 8;45:24-35. doi: 10.1016/j.jot.2023.12.006. eCollection 2024 Mar.
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