Department of Laboratory Medicine, University Hospitals Leuven, Belgium; Department of Development and Regeneration, KU Leuven, Belgium.
Department of Orthopaedic and Trauma Surgery, University Hospital Basel, Switzerland.
Clin Microbiol Infect. 2020 May;26(5):572-578. doi: 10.1016/j.cmi.2019.08.006. Epub 2019 Aug 22.
Both fracture-related infections (FRIs) and periprosthetic joint infections (PJIs) include orthopaedic implant-associated infections. However, key aspects of management differ due to the bone and soft tissue damage in FRIs and the option of removing the implant after fracture healing. In contrast to PJIs, research and guidelines for diagnosis and treatment in FRIs are scarce.
This narrative review aims to update clinical microbiologists, infectious disease specialists and surgeons on the management of FRIs.
A computerized search of PubMed was performed to identify relevant studies. Search terms included 'Fracture' and 'Infection'. The reference lists of all retrieved articles were checked for additional relevant references. In addition, when scientific evidence was lacking, recommendations are based on expert opinion.
Pathogenesis, prevention, diagnosis and treatment of FRIs are presented. Whenever available, specific data of patients with FRI are discussed.
Management of patients with FRI should take into account FRI-specific features. Treatment pathways should implement a multidisciplinary approach to achieve a good outcome. Recently, international consensus guidelines were developed to improve the quality of care for patients suffering from this severe complication, which are highlighted in this review.
骨折相关感染（FRI）和人工关节周围感染（PJI）都属于骨科植入物相关感染。然而，由于 FRI 会造成骨和软组织损伤，且骨折愈合后可以选择取出植入物，其治疗方法与 PJI 存在关键差异。与 PJI 相比，FRI 的诊断和治疗的研究和指南还很匮乏。
本文旨在为临床微生物学家、传染病专家和外科医生提供 FRI 管理的最新信息。
通过计算机检索 PubMed 以确定相关研究。检索词包括“骨折”和“感染”。查阅所有检索到的文章的参考文献列表，以获取其他相关参考文献。此外，当缺乏科学证据时，建议则基于专家意见。
介绍了 FRI 的发病机制、预防、诊断和治疗。只要有相关数据，就会讨论 FRI 患者的具体情况。
FRI 患者的管理应考虑到 FRI 的特定特征。治疗方案应采用多学科方法，以实现良好的治疗效果。最近，国际上制定了共识指南来提高此类严重并发症患者的护理质量，本文对此进行了重点介绍。
