Jensen O J, Poulsen T, Schiødt T
Department of Pathology, Rigshospitalet, Copenhagen, Denmark.
APMIS. 1988 May;96(5):421-7.
Mucoepidermoid tumors of salivary glands are relative rare and it has often been difficult to correlate the pathologic features and clinical aspects. The literature recommends long term follow-up studies. The object of the present study was therefore to follow this recommendation. The clinico-pathological features of 39 mucoepidermoid tumors are presented. The material was retrieved from the files of the pathological institute, Rigshospitalet, Copenhagen, during the period 1941-75. All patients, 24 males, 15 females, were followed for a minimum of 5 years. The lesions were classified into low grade (13 cases), intermediate grade (14 cases) and high grade (12 cases). The corresponding 5, 10 and 15 years cumulative survival rates were 92%, 92%, 92% for low grade, 47.4%, 47.4%, 35.5% for intermediate grade and 0%, 0%, 0% for high grade tumors. Thus we found a close correlation between pathology and clinical course. Furthermore, a 5 year observation period appeared an acceptable approach, because 17 of the 18 patients who succumbed of the disease, did so within 4 years following surgery. We consider all grades of mucoepidermoid tumors to be potential malignant. In our study one patient with a low grade tumor died of the disease.
涎腺黏液表皮样肿瘤相对少见，而且常常难以将病理特征与临床情况联系起来。文献推荐进行长期随访研究。因此，本研究的目的就是遵循这一建议。本文介绍了39例黏液表皮样肿瘤的临床病理特征。研究材料取自哥本哈根市 Rigshospitalet 病理研究所1941年至1975年期间的档案。所有患者，24例男性，15例女性，均接受了至少5年的随访。这些病变被分为低级别（13例）、中级别（14例）和高级别（12例）。低级别肿瘤对应的5年、10年和15年累积生存率分别为92%、92%、92%，中级别肿瘤分别为47.4%、47.4%、35.5%，高级别肿瘤分别为0%、0%、0%。因此，我们发现病理与临床病程之间存在密切关联。此外，5年的观察期似乎是一种可接受的方法，因为18例死于该病的患者中有17例是在手术后4年内死亡的。我们认为所有级别的黏液表皮样肿瘤都有潜在的恶性可能。在我们的研究中，1例低级别肿瘤患者死于该病。
