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Targeting the nitrate-nitrite-nitric oxide pathway in heart failure with preserved ejection fraction: too soon to say no to nitric oxide?针对射血分数保留的心力衰竭中的硝酸盐-亚硝酸盐-一氧化氮途径：现在就对一氧化氮说“不”是否为时过早？
Eur J Heart Fail. 2021 May;23(5):824-825. doi: 10.1002/ejhf.2171. Epub 2021 Apr 12.
2
The Nitrate-Nitrite-NO Pathway and Its Implications for Heart Failure and Preserved Ejection Fraction.硝酸盐-亚硝酸盐-一氧化氮途径及其对心力衰竭和射血分数保留的影响。
Curr Heart Fail Rep. 2016 Feb;13(1):47-59. doi: 10.1007/s11897-016-0277-9.
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Harnessing the nitrate-nitrite-nitric oxide pathway for therapy of heart failure with preserved ejection fraction.利用硝酸盐-亚硝酸盐-一氧化氮途径治疗射血分数保留的心力衰竭。
Circulation. 2015 Jan 27;131(4):334-6. doi: 10.1161/CIRCULATIONAHA.114.014149. Epub 2014 Dec 22.
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The Nitrate-Nitrite-NO Pathway as a Novel Therapeutic Target in Heart Failure with Reduced Ejection Fraction.硝酸盐-亚硝酸盐-一氧化氮途径作为射血分数降低的心力衰竭的新型治疗靶点。
J Card Fail. 2018 Feb;24(2):74-77. doi: 10.1016/j.cardfail.2017.12.001. Epub 2017 Dec 13.
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INDIE-HFpEF (Inorganic Nitrite Delivery to Improve Exercise Capacity in Heart Failure With Preserved Ejection Fraction): Rationale and Design.INDIE-HFpEF（无机亚硝酸盐给药改善射血分数保留的心力衰竭患者运动能力）：原理与设计
Circ Heart Fail. 2017 May;10(5). doi: 10.1161/CIRCHEARTFAILURE.117.003862.
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Effects of supervised exercise and dietary nitrate in older adults with controlled hypertension and/or heart failure with preserved ejection fraction.监督锻炼和饮食硝酸盐对血压控制良好的老年高血压和/或射血分数保留心力衰竭患者的影响。
Nitric Oxide. 2017 Sep 30;69:78-90. doi: 10.1016/j.niox.2017.05.005. Epub 2017 May 23.
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Effect of inorganic nitrate on exercise capacity in heart failure with preserved ejection fraction.无机硝酸盐对射血分数保留的心力衰竭患者运动能力的影响。
Circulation. 2015 Jan 27;131(4):371-80; discussion 380. doi: 10.1161/CIRCULATIONAHA.114.012957. Epub 2014 Dec 22.
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Multiple Avenues of Modulating the Nitric Oxide Pathway in Heart Failure Clinical Trials.心力衰竭临床试验中调节一氧化氮途径的多种方法
Curr Heart Fail Rep. 2018 Apr;15(2):44-52. doi: 10.1007/s11897-018-0383-y.
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Direct demonstration of NO formation in vivo from organic nitrites and nitrates, and correlation to effects on blood pressure and to in vitro effects.直接证明体内有机亚硝酸盐和硝酸盐可形成一氧化氮，并将其与对血压的影响以及体外效应相关联。
Biochem Pharmacol. 1994 Mar 15;47(6):1047-53. doi: 10.1016/0006-2952(94)90416-2.

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The Generation of Nitric Oxide from Aldehyde Dehydrogenase-2: The Role of Dietary Nitrates and Their Implication in Cardiovascular Disease Management.从醛脱氢酶 2 生成一氧化氮：膳食硝酸盐的作用及其在心血管疾病管理中的意义。
Int J Mol Sci. 2022 Dec 7;23(24):15454. doi: 10.3390/ijms232415454.
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Nitric oxide metabolites: associations with cardiovascular biomarkers and clinical parameters in patients with HFpEF.一氧化氮代谢物：与 HFpEF 患者心血管生物标志物和临床参数的关系。
ESC Heart Fail. 2022 Dec;9(6):3961-3972. doi: 10.1002/ehf2.14116. Epub 2022 Aug 18.

本文引用的文献

1
Searching for the Optimal Exercise Training Regimen in Heart Failure With Preserved Ejection Fraction.寻找射血分数保留的心力衰竭的最佳运动训练方案。
JAMA. 2021 Feb 9;325(6):537-539. doi: 10.1001/jama.2020.26347.
2
Peripheral and pulmonary effects of inorganic nitrite during exercise in heart failure with preserved ejection fraction.运动时射血分数保留的心力衰竭患者中无机亚硝酸盐的外周和肺效应。
Eur J Heart Fail. 2021 May;23(5):814-823. doi: 10.1002/ejhf.2093. Epub 2021 Feb 1.
3
Effect of Vericiguat vs Placebo on Quality of Life in Patients With Heart Failure and Preserved Ejection Fraction: The VITALITY-HFpEF Randomized Clinical Trial.维立西呱对比安慰剂对射血分数保留的心力衰竭患者生活质量的影响：VITALITY-HFpEF 随机临床试验。
JAMA. 2020 Oct 20;324(15):1512-1521. doi: 10.1001/jama.2020.15922.
4
Evaluation and management of heart failure with preserved ejection fraction.射血分数保留的心力衰竭的评估和管理。
Nat Rev Cardiol. 2020 Sep;17(9):559-573. doi: 10.1038/s41569-020-0363-2. Epub 2020 Mar 30.
5
Effect of Inorganic Nitrite vs Placebo on Exercise Capacity Among Patients With Heart Failure With Preserved Ejection Fraction: The INDIE-HFpEF Randomized Clinical Trial.无机亚硝酸盐与安慰剂对射血分数保留的心力衰竭患者运动能力的影响：INDIE-HFpEF 随机临床试验。
JAMA. 2018 Nov 6;320(17):1764-1773. doi: 10.1001/jama.2018.14852.
6
Relative Impairments in Hemodynamic Exercise Reserve Parameters in Heart Failure With Preserved Ejection Fraction: A Study-Level Pooled Analysis.射血分数保留的心力衰竭患者血流动力学运动储备参数的相对损害：一项研究水平的汇总分析。
JACC Heart Fail. 2018 Feb;6(2):117-126. doi: 10.1016/j.jchf.2017.10.014.
7
Exercise Intolerance in Heart Failure With Preserved Ejection Fraction: Diagnosing and Ranking Its Causes Using Personalized O Pathway Analysis.射血分数保留的心力衰竭中的运动不耐受：使用个性化 O 通路分析诊断和分级其病因。
Circulation. 2018 Jan 9;137(2):148-161. doi: 10.1161/CIRCULATIONAHA.117.029058. Epub 2017 Oct 9.
8
Inorganic vs. organic nitrates for heart failure with preserved ejection fraction: it's not all in your head!射血分数保留的心力衰竭患者使用无机硝酸盐与有机硝酸盐的比较：并非全凭主观判断！
Eur J Heart Fail. 2017 Nov;19(11):1516-1519. doi: 10.1002/ejhf.966. Epub 2017 Sep 11.
9
Inhaled Sodium Nitrite Improves Rest and Exercise Hemodynamics in Heart Failure With Preserved Ejection Fraction.吸入亚硝酸钠可改善射血分数保留的心力衰竭患者静息和运动时的血流动力学。
Circ Res. 2016 Sep 16;119(7):880-6. doi: 10.1161/CIRCRESAHA.116.309184. Epub 2016 Jul 25.
10
Effect of Caloric Restriction or Aerobic Exercise Training on Peak Oxygen Consumption and Quality of Life in Obese Older Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial.热量限制或有氧运动训练对射血分数保留的肥胖老年心力衰竭患者峰值耗氧量和生活质量的影响：一项随机临床试验。
JAMA. 2016 Jan 5;315(1):36-46. doi: 10.1001/jama.2015.17346.

Targeting the nitrate-nitrite-nitric oxide pathway in heart failure with preserved ejection fraction: too soon to say no to nitric oxide?

作者信息

Wan Siu-Hin, Pandey Ambarish

机构信息

Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

出版信息

Eur J Heart Fail. 2021 May;23(5):824-825. doi: 10.1002/ejhf.2171. Epub 2021 Apr 12.

DOI:10.1002/ejhf.2171
PMID:33779018
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8259878/
Abstract
摘要