Steele K, Shirodaria P, O'Hare M, Merrett J D, Irwin W G, Simpson D I, Pfister H
Department of General Practice, Dunluce Health Centre, Belfast, Northern Ireland.
Br J Dermatol. 1988 Apr;118(4):537-43. doi: 10.1111/j.1365-2133.1988.tb02464.x.
Monochloroacetic acid crystals and 60% salicylic acid ointment was found to be more effective than placebo as a treatment for simple plantar warts in a double blind study on 57 patients. Nineteen (66%) patients in the active treatment group compared with five (18%) patients in the placebo group were cured after 6 weeks (P = 0.002). The active treatment was associated with a significantly higher cure rate 6 months after entry (P = 0.04). Treatments were well tolerated. IgG or IgM antibodies or both to human papilloma virus (HPV) types 1 or 2 or both were detected significantly more frequently in the actively treated group 6 weeks after entry (P = 0.0005). Twelve (50%) patients considered to be cured had no detectable secondary immune response. Our results suggest that cure does not depend primarily on the humoral system but rather on mechanical destruction of wart tissue, or occurs as a result of cell mediated immunity.
在一项针对57名患者的双盲研究中，发现一氯乙酸晶体和60%水杨酸软膏作为单纯跖疣的治疗方法比安慰剂更有效。活性治疗组19名（66%）患者与安慰剂组5名（18%）患者在6周后治愈（P = 0.002）。活性治疗在入组6个月后的治愈率显著更高（P = 0.04）。治疗耐受性良好。在入组6周后，活性治疗组中检测到针对1型或2型人乳头瘤病毒（HPV）或两者的IgG或IgM抗体或两者的频率显著更高（P = 0.0005）。12名（50%）被认为治愈的患者没有可检测到的二次免疫反应。我们的结果表明，治愈并不主要依赖于体液系统，而是依赖于疣体组织的机械破坏，或者是细胞介导免疫的结果。
