格雷夫斯病和桥本甲状腺炎中的免疫复合物沉积。

Immune complex deposits in Graves' disease and Hashimoto's thyroiditis.

作者信息

Kalderon A E, Bogaars H A

出版信息

Am J Med. 1977 Nov;63(5):729-34. doi: 10.1016/0002-9343(77)90159-0.

Abstract

The thyroid glands of four patients with Graves' disease and five patients with Hashimoto's thyroiditis were investigated to demonstrate in vivo immune complex deposition. By electron microscopy, electron-dense deposits were observed in the follicular basal lamina--basement membrane--(FBL) often associated with lymphocytic and plasma cell infiltration. A positive correlation was obtained with all cases by immunofluorescent studies using anti-IgG, IgA, IgM, C3 and antithyroglobulin conjugated serums. The staining was of a granular pattern and coincided to the FBL region. No discrepancies were noted in electron microscopic and immunofluorescent observations between patients with Graves' disease and Hashimoto's thyroiditis, and the occasional observation of immune complexes in areas devoid of infiltrate in some patients with Graves' disease. Morphologically, the deposits were found to be similar to those described in the Obese Strain chickens with spontaneous autoimmune thyroiditis.

摘要

对4例格雷夫斯病患者和5例桥本甲状腺炎患者的甲状腺进行了研究，以证明体内免疫复合物的沉积。通过电子显微镜观察，在滤泡基底层——基底膜——（FBL）中观察到电子致密沉积物，常伴有淋巴细胞和浆细胞浸润。使用抗IgG、IgA、IgM、C3和抗甲状腺球蛋白结合血清进行免疫荧光研究，所有病例均呈正相关。染色呈颗粒状，与FBL区域一致。格雷夫斯病患者和桥本甲状腺炎患者在电子显微镜和免疫荧光观察方面没有差异，在一些格雷夫斯病患者中偶尔在无浸润区域观察到免疫复合物。形态学上，这些沉积物与肥胖品系鸡自发性自身免疫性甲状腺炎中描述的沉积物相似。