Chemical Engineering Program, Department of Advanced Science and Engineering, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashihiroshima 739-8527, Japan.
Department of Bioresources Technology and Veterinary, Vocational College, Gadjah Mada University, Sekip Unit 1 Catur Tunggal, Depok Sleman, D.I. Yogyakarta 55281, Indonesia.
Langmuir. 2021 Apr 13;37(14):4256-4266. doi: 10.1021/acs.langmuir.1c00232. Epub 2021 Mar 29.
Many types of porous particles containing inorganic and organic substances, such as carbon, metals, metal oxides, inorganic-organic hybrids, and polymers, have been developed. However, natural polymer-derived particles are relatively rare. To our knowledge, this report describes the first synthetic method for obtaining meso-/macroporous particles made from pectin, which is a natural polymer with a wide range of biological activities suitable for active substance support applications. These porous particles were prepared using a template-assisted spray-drying method, followed by a chemical etching process. An organic template [i.e., poly(methyl methacrylate) (PMMA)] or an inorganic template [i.e., calcium carbonate (CaCO)] was used to evaluate the resulting formation of macroporous structures in the pectin particles. Furthermore, the concentration of the templates in the precursor solution was varied to better understand the mechanism of porous pectin particle formation. The results showed that the final porous particles maintained the characteristic properties of pectin. The differences between the two templates resulted in two distinct types of porous particles that differed in their particle morphologies (i.e., spherical or wrinkled), particle sizes (ranging from 3 to 8 μm), pore sizes (ranging from 80 to 350 nm), and pore volume (ranging from 0.024 to 1.40 cm g). Especially, the porous pectin particles using the CaCO template have a significantly high specific surface area of 171.2 m g, which is 114 times higher than that of nonporous pectin particles. These data demonstrated the potential for using PMMA and CaCO templates to control and design desired porous materials.
已经开发出了许多种含有无机和有机物质的多孔颗粒，例如碳、金属、金属氧化物、无机-有机杂化材料和聚合物等。然而，天然聚合物衍生的颗粒相对较少。据我们所知，本报告描述了首次使用果胶（一种具有广泛生物活性的天然聚合物，适用于活性物质支持应用）合成介孔/大孔颗粒的方法。这些多孔颗粒是使用模板辅助喷雾干燥法，然后进行化学刻蚀工艺制备的。使用有机模板（即聚甲基丙烯酸甲酯（PMMA））或无机模板（即碳酸钙（CaCO ））来评估果胶颗粒中大孔结构的形成情况。此外，还改变了前体溶液中模板的浓度，以更好地理解形成多孔果胶颗粒的机制。结果表明，最终的多孔颗粒保持了果胶的特征性质。两种模板的差异导致了两种不同类型的多孔颗粒，它们在颗粒形态（即球形或皱缩形）、颗粒尺寸（3 到 8 μm 之间）、孔径（80 到 350nm 之间）和孔体积（0.024 到 1.40cm g 之间）方面存在差异。特别是，使用 CaCO 模板的多孔果胶颗粒具有非常高的比表面积（171.2m g ），是无孔果胶颗粒的 114 倍。这些数据表明，PMMA 和 CaCO 模板可用于控制和设计所需的多孔材料。
