Ghanbari Adivi Fatemeh, Hashemi Payman
Department of Chemistry, Faculty of Science, Lorestan University, Khoramabad 6815144316, Iran.
Department of Chemistry, Faculty of Science, Lorestan University, Khoramabad 6815144316, Iran.
Colloids Surf B Biointerfaces. 2021 Jul;203:111717. doi: 10.1016/j.colsurfb.2021.111717. Epub 2021 Mar 22.
A three-step process was developed for the synthesis of magnetic iron oxide nanoparticles coated with agarose, their functionalization with iminodiacetic acid (IDA) and layering of the particles with a silica shell. The prepared FeO@Agarose/IDA@Silica nanoparticles were characterized by scanning electron microscopy, energy dispersive X-ray analysis and Fourier transform infrared spectroscopy. Ion mobility spectrometry (IMS) was successfully used for the ultrafast and interference free determination of histamine in serum samples in this work. Effect of different parameters on histamine adsorption by the nanoparticles such as pH, ionic strength, contact time and adsorbent amount were investigated. Under the optimized conditions, adsorption capacities up to 178 mg g of the adsorbent were obtained. For interpreting histamine adsorption on the nanoparticles, the adsorption isotherms were studied and the Freundlich model was found to be more applicable than the Langmuir model. It was found that the prepared nanoparticles could remove up to 92 % of histamine from human serum samples.
开发了一种三步法来合成包覆有琼脂糖的磁性氧化铁纳米颗粒，用亚氨基二乙酸（IDA）对其进行功能化，并在颗粒上包覆二氧化硅壳层。通过扫描电子显微镜、能量色散X射线分析和傅里叶变换红外光谱对制备的FeO@琼脂糖/IDA@二氧化硅纳米颗粒进行了表征。在这项工作中，离子迁移谱（IMS）成功用于血清样品中组胺的超快速和无干扰测定。研究了不同参数（如pH值、离子强度、接触时间和吸附剂用量）对纳米颗粒吸附组胺的影响。在优化条件下，吸附剂的吸附容量高达178 mg/g。为了解释组胺在纳米颗粒上的吸附情况，研究了吸附等温线，发现Freundlich模型比Langmuir模型更适用。结果发现，制备的纳米颗粒可从人血清样品中去除高达92%的组胺。
