3D CoPt 纳米结构与铱配合物杂化用于多模态成像及联合光热-化学治疗。
3D CoPt nanostructures hybridized with iridium complexes for multimodal imaging and combined photothermal-chemotherapy.
机构信息
MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China.
State Key Laboratory of Ophthalmology, Optometry and Vision Science, School of Ophthalmology and Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou 325027, China; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, China.
出版信息
J Inorg Biochem. 2021 Jun;219:111429. doi: 10.1016/j.jinorgbio.2021.111429. Epub 2021 Mar 19.
Combined photothermal-chemotherapy has shown great potential in improving the efficiency of tumor treatment. In this article, we have designed a new type of nanocomposite Ir-CoPt-PVP composed of cobalt/platinum alloy nanoparticles (CoPt) and iridium(III) complex (Ir) for combined photothermal therapy (PTT) and chemotherapy. The obtained CoPt was synthesized by a simple solvothermal method and modified by polyvinyl pyrrolidone (PVP), which exhibited excellent photothermal efficiency and stability, and can also be a bimodal bioimaging contrast agent in photothermal imaging (PTI) and photoacoustic imaging (PAI). Furthermore, the combination therapy has shown obvious tumor cell-growth inhibition in vitro. Overall, the results revealed the great potential of Ir-CoPt-PVP nanocomposites in improving therapeutic efficiency by photothermal-chemotherapy and photothermal/photoacoustic imaging.
联合光热-化学疗法在提高肿瘤治疗效率方面显示出巨大的潜力。在本文中，我们设计了一种新型纳米复合材料 Ir-CoPt-PVP，由钴/铂合金纳米粒子 (CoPt) 和铱(III)配合物 (Ir) 组成，用于联合光热治疗 (PTT) 和化学疗法。所得到的 CoPt 通过简单的溶剂热法合成，并通过聚乙烯吡咯烷酮 (PVP) 进行修饰，表现出优异的光热效率和稳定性，并且还可以作为光热成像 (PTI) 和光声成像 (PAI) 中的双模态生物成像对比剂。此外，联合治疗在体外显示出明显的肿瘤细胞生长抑制作用。总体而言，结果表明 Ir-CoPt-PVP 纳米复合材料在通过光热-化学疗法和光热/光声成像提高治疗效率方面具有巨大的潜力。
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