MAL2 通过增加 ERK1/2 磷酸化与 IQGAP1 相互作用促进胰腺癌进展。
MAL2 interacts with IQGAP1 to promote pancreatic cancer progression by increasing ERK1/2 phosphorylation.
机构信息
Department of Digestive Surgical Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
Department of Digestive Surgical Oncology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
出版信息
Biochem Biophys Res Commun. 2021 May 21;554:63-70. doi: 10.1016/j.bbrc.2021.02.146. Epub 2021 Mar 26.
Pancreatic cancer is a digestive tract malignancy characterized by an occult onset and rapid progression. The genetic heterogeneity of pancreatic cancer is closely related to its highly malignant biological behavior. The myelin and lymphocyte protein 2 (MAL2) is upregulated in multiple cancers at the transcriptional level. However, the exact role of MAL2 in pancreatic cancer remains elusive. In this study, we demonstrated that MAL2 protein and mRNA levels were upregulated in pancreatic cancer. MAL2 overexpression was significantly associated with poor prognosis in patients with pancreatic cancer. We further showed that MAL2 interacted with IQGAP1 to increase ERK1/2 phosphorylation levels, which promoted pancreatic cancer progression. Therefore, these results suggest that MAL2 could be a novel therapeutic target for pancreatic cancer.
胰腺癌是一种消化道恶性肿瘤，其特点为隐匿起病和快速进展。胰腺癌的遗传异质性与其高度恶性的生物学行为密切相关。髓鞘和淋巴细胞蛋白 2（MAL2）在转录水平上在多种癌症中上调。然而，MAL2 在胰腺癌中的确切作用仍不清楚。在本研究中，我们证明了 MAL2 蛋白和 mRNA 水平在胰腺癌中上调。MAL2 过表达与胰腺癌患者的不良预后显著相关。我们进一步表明，MAL2 与 IQGAP1 相互作用以增加 ERK1/2 磷酸化水平，从而促进胰腺癌的进展。因此，这些结果表明 MAL2 可能是胰腺癌的一个新的治疗靶点。
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