Anatomy-guided PET reconstruction usingbowsher prior.

Advances in simultaneous positron emission tomography/magnetic resonance imaging (PET/MRI) technology have led to an active investigation of the anatomy-guided regularized PET image reconstruction algorithm based on MR images. Among the various priors proposed for anatomy-guided regularized PET image reconstruction, Bowsher's method based on second-order smoothing priors sometimes suffers from over-smoothing of detailed structures. Therefore, in this study, we propose a Bowsher prior based on thel1-norm and an iteratively reweighting scheme to overcome the limitation of the original Bowsher method. In addition, we have derived a closed solution for iterative image reconstruction based on this non-smooth prior. A comparison study between the originall2and proposedl1Bowsher priors was conducted using computer simulation and real human data. In the simulation and real data application, small lesions with abnormal PET uptake were better detected by the proposedl1Bowsher prior methods than the original Bowsher prior. The originall2Bowsher leads to a decreased PET intensity in small lesions when there is no clear separation between the lesions and surrounding tissue in the anatomical prior. However, the proposedl1Bowsher prior methods showed better contrast between the tumors and surrounding tissues owing to the intrinsic edge-preserving property of the prior which is attributed to the sparseness induced byl1-norm, especially in the iterative reweighting scheme. Besides, the proposed methods demonstrated lower bias and less hyper-parameter dependency on PET intensity estimation in the regions with matched anatomical boundaries in PET and MRI. Therefore, these methods will be useful for improving the PET image quality based on the anatomical side information.