Grivas Grigoris, Lagousi Theano, Mandilara Georgia
Penteli Children's Hospital, Pediatric Intensive Care Unit, Athens, Greece.
Infectious Diseases Unit and University Research Institute for the Study of Genetic & Malignant Disorders in Childhood, 1st Department of Paediatrics, Aghia Sofia Children's Hospital, National and Kapodistrian University of Athens, Athens, Greece; Penteli Children's Hospital, Department of Pediatrics, Athens, Greece.
Acta Med Acad. 2020 Dec;49(3):255-264. doi: 10.5644/ama2006-124.315.
This study aimed to describe Salmonella epidemiology and antimicrobial resistance in Greek children over the period of 2011-2017.
A 7-year retrospective study (2011-2017) was performed, based on data recorded by the National Reference Centre for Salmonella, among children aged ≤14 years. Epidemiological data, serovar distribution and antimicrobial resistance patterns were recorded.
Overall, 2347 Salmonella isolates were collected (27 typhoid-paratyphoid). Salmonellosis cases increased by almost 2-fold in 2017 compared to 2011. The highest rates were reported in August, with infants being the most vulnerable group (17.9%). The majority of isolates were identified in stool samples (91%). Boys slightly outnumbered girls (˜1.05:1). Salmonella Enteritidis was the most prevalent serovar (28.5%), followed by Salmonella Typhimurium (12.2%) and Salmonella monophasic Typhimurium (10.4%). Non-typhoid isolates displayed low resistance rates to 3rd generation cephalosporins (1%) and ciprofloxacin (0.3%), while the corresponding resistance of typhoid isolates was 10% and 5% respectively. An increasing trend of Salmonella monophasic Typhimurium was recorded, associated with high rates of multidrug resistance, reaching a percentage of 97.8% in 2017.
Salmonellosis epidemiology in Greek children is comparable to previously published European data. Antimicrobial resistance rates to 3rd-generation cephalosporins and ciprofloxacin for non-typhoid and typhoid-paratyphoid remain low. Notably, there is an increasing prevalence of Salmonella monophasic Typhimurium isolates, associated with multiple antimicrobial resistance.
本研究旨在描述2011 - 2017年期间希腊儿童沙门氏菌的流行病学情况及抗菌药物耐药性。
基于沙门氏菌国家参考中心记录的数据，对14岁及以下儿童进行了一项为期7年的回顾性研究（2011 - 2017年）。记录了流行病学数据、血清型分布和抗菌药物耐药模式。
总体而言，共收集到2347株沙门氏菌分离株（27株伤寒 - 副伤寒菌）。与2011年相比，2017年沙门氏菌病病例增加了近两倍。8月份报告的发病率最高，婴儿是最易感染群体（17.9%）。大多数分离株在粪便样本中被鉴定出来（91%）。男孩略多于女孩（约1.05:1）。肠炎沙门氏菌是最常见的血清型（28.5%），其次是鼠伤寒沙门氏菌（12.2%）和单相鼠伤寒沙门氏菌（10.4%）。非伤寒分离株对第三代头孢菌素（1%）和环丙沙星（0.3%）的耐药率较低，而伤寒分离株的相应耐药率分别为10%和5%。记录到单相鼠伤寒沙门氏菌呈上升趋势，与多重耐药率高相关，2017年达到97.8%。
希腊儿童沙门氏菌病的流行病学情况与先前发表的欧洲数据相当。非伤寒和伤寒 - 副伤寒对第三代头孢菌素和环丙沙星的抗菌药物耐药率仍然较低。值得注意的是，单相鼠伤寒沙门氏菌分离株的患病率在上升，且与多重抗菌药物耐药相关。
