Department of Neonatology, Faculty of Medicine in Ostrava, University Hospital Ostrava, Ostrava University, Ostrava, Czech Republic.
Department of Obstetrics and Gynecology, Faculty of Medicine in Hradec Kralove, University Hospital Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.
J Matern Fetal Neonatal Med. 2022 Dec;35(25):5993-5998. doi: 10.1080/14767058.2021.1903859. Epub 2021 Mar 29.
To perform a systematic review of the literature available on the association between the presence of microbial invasion of the amniotic cavity (MIAC) and/or intra-amniotic inflammation and long-term neurodevelopmental outcomes of infants from pregnancies complicated by preterm prelabor rupture of membranes (PPROM).
A literature search, from their earliest entries to May 2020, was performed by employing three electronic databases (Web of Science, PubMed, and Scopus). The selection criteria were as follows: (1) singleton pregnancies with PPROM; (2) available information regarding MIAC and/or intra-amniotic inflammation; (3) long-term (at least one year of the corrected age) neurodevelopmental outcomes of respective infants.
The initial search identified 10,953 articles, of which 8 were selected for full-text reading; however, none were included in the review owing to the following reasons: (i) spontaneous preterm labor with intact membranes and/or indicated (iatrogenic) preterm delivery were included in the studies without providing separate data for PPROM ( = 5); (ii) long-term, at least one year of the corrected age, neurodevelopmental outcomes of infants were not assessed ( = 1); (iii) the presence of both the abovementioned reasons ( = 1); (iv) amniotic fluid was not assessed, and a long-term neurodevelopmental outcome was not evaluated ( = 1).
The literature search provides evidence of a knowledge gap in the association between the presence of MIAC and/or intra-amniotic inflammation and long-term neurodevelopmental outcomes in infants with PPROM.
系统回顾文献中关于胎膜早破（PPROM）孕妇羊膜腔内微生物入侵（MIAC）和/或羊膜内炎症与婴儿长期神经发育结局之间关系的研究。
从最早记录到 2020 年 5 月，使用三个电子数据库（Web of Science、PubMed 和 Scopus）进行文献检索。选择标准如下：（1）单胎妊娠伴 PPROM；（2）有 MIAC 和/或羊膜内炎症的信息；（3）各自婴儿的长期（至少校正年龄 1 年）神经发育结局。
最初的搜索确定了 10953 篇文章，其中 8 篇被选为全文阅读；然而，由于以下原因，没有一篇被纳入综述：（i）包括胎膜完整的自发性早产和/或有指征的（医源性）早产，且没有为 PPROM 提供单独的数据（5 篇）；（ii）未评估婴儿长期（至少校正年龄 1 年）的神经发育结局（1 篇）；（iii）同时存在上述两个原因（1 篇）；（iv）未评估羊水情况，也未评估长期神经发育结局（1 篇）。
文献检索结果表明，在 PPROM 婴儿中，MIAC 和/或羊膜内炎症与长期神经发育结局之间的关系存在知识空白。
