反复电惊厥休克可使遗传性肥胖小鼠（C57BL/6J ob/ob）的血糖水平恢复正常，但对遗传性糖尿病小鼠（C57BL/KsJ db/db）则无效。
Repeated electroconvulsive shock normalizes blood glucose levels in genetically obese mice (C57BL/6J ob/ob) but not in genetically diabetic mice (C57BL/KsJ db/db).
作者信息
Nutt D J, Gleiter C H, Linnoila M
机构信息
Laboratory of Clinical Studies, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD 20892.
出版信息
Brain Res. 1988 May 17;448(2):377-80. doi: 10.1016/0006-8993(88)91281-4.
There are several conflicting reports on the effect of electroconvulsive shock (ECS) on diabetes in humans. The present study investigated the effect of repeated ECS on blood glucose levels in genetically obese mice, which are considered an animal model for non-insulin dependent (maturity onset) diabetes. These mice were compared with genetically diabetic mice which are thought to be an animal model for insulin-dependent (juvenile-type) diabetes. A marked decrease in blood glucose concentrations was observed in obese mice after the first ECS which lasted for 14 days after the last ECS. No effect was seen in genetically diabetic mice. The neural mechanisms by which ECS normalizes blood glucose in genetically obese mice are discussed.
关于电惊厥休克（ECS）对人类糖尿病的影响，有几份相互矛盾的报告。本研究调查了重复ECS对基因肥胖小鼠血糖水平的影响，这些小鼠被认为是非胰岛素依赖型（成年发病型）糖尿病的动物模型。将这些小鼠与被认为是胰岛素依赖型（青少年型）糖尿病动物模型的基因糖尿病小鼠进行比较。在首次ECS后，肥胖小鼠的血糖浓度显著降低，这种降低在最后一次ECS后持续了14天。在基因糖尿病小鼠中未观察到影响。文中讨论了ECS使基因肥胖小鼠血糖正常化的神经机制。
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