Drinovec J, Bren A, Gucek A, Lindic J, Kandus A, Ponikvar R
Department of Nephrology, University Medical Center, Ljublijana, Yugoslavia.
Chemioterapia. 1988 Feb;7(1):46-8.
The aim of this prospective, randomized, open study was to survey the frequency course and to evaluate the therapy of peritonitis induced by staphylococci in patients on continuous ambulatory peritoneal dialysis (CAPD). From June 1983 to November 1986, 20 patients (9 men, 11 women) aged from 25 to 73 were treated. During 258 months of the CAPD treatment they had 54 episodes of peritonitis. Staphylococcus saprophyticus was the most frequent offender of peritonitis, isolated from peritoneal effluent in 44% of the cases, Staphylococcus epidermidis was isolated in 7% of the cases. Staphylococcus aureus was isolated in 5% of the cases and caused a more severe form of peritonitis. The combination of gentamicin and methicillin was used in 14 cases, in 2 cases this treatment was unsuccessful. A combination of gentamicin and cloxacillin was used in 5 cases and a combination of clindamycin and mezlocillin in 12 cases of peritonitis, giving good results in all cases. The last combination seemed to be the most effective in the treatment of staphylococcus induced peritonitis.
这项前瞻性、随机、开放性研究的目的是调查持续性非卧床腹膜透析（CAPD）患者葡萄球菌性腹膜炎的发病频率过程并评估其治疗方法。1983年6月至1986年11月，对20例年龄在25至73岁之间的患者（9名男性，11名女性）进行了治疗。在CAPD治疗的258个月期间，他们发生了54次腹膜炎发作。腐生葡萄球菌是腹膜炎最常见的致病菌，44%的病例从腹膜透析液中分离出该菌，表皮葡萄球菌在7%的病例中被分离出。金黄色葡萄球菌在5%的病例中被分离出，且引发了更严重的腹膜炎形式。14例患者使用庆大霉素和甲氧西林联合治疗，其中2例治疗失败。5例腹膜炎患者使用庆大霉素和氯唑西林联合治疗，12例腹膜炎患者使用克林霉素和美洛西林联合治疗，所有病例均取得了良好效果。最后一种联合治疗方法似乎是治疗葡萄球菌性腹膜炎最有效的方法。
