Lab for Bone Metabolism, Xi'an Key Laboratory of Special Medicine and Health Engineering, Key Lab for Space Biosciences and Biotechnology, Research Center for Special Medicine and Health Systems Engineering, NPU-UAB Joint Laboratory for Bone Metabolism, School of Life Sciences, Northwestern Polytechnical University, Xi'an, China.
Biological Effects and Technology Division, Institute for Hygiene of Ordnance Industry, Xi'an, China.
J Appl Toxicol. 2021 Nov;41(11):1803-1815. doi: 10.1002/jat.4164. Epub 2021 Mar 29.
Polycyclic aromatic hydrocarbons (PAHs) are the most common contaminants in the air pollutants. Inhalation exposure to PAHs could increase the risk of respiratory disease, cardiovascular disease and even cancer. However, the biotoxicity of multi-component PAHs from atmospheric pollutants has been poorly studies. The main topic of this study was to investigate the PAHs mixture, which derived from atmospheric pollutants, induced toxic effects and inflammatory effects on human bronchial epithelial cells in vitro. The results showed that PAHs mixture could decrease the cell viability, increase the apoptosis rate, and induce cell cycle arrest at S-phase. Furthermore, the expression of inflammatory factors IL-1β and IL-6 were increased and NF-κB signaling pathway was activated in PAHs mixture-treated cells. The findings of this study indicate that PAHs mixture-induced cytotoxicity and inflammation may be related to intracellular ROS generation and to the activated NF-κB signaling pathway.
多环芳烃（PAHs）是空气污染物中最常见的污染物。吸入多环芳烃会增加患呼吸道疾病、心血管疾病甚至癌症的风险。然而，大气污染物中多组分多环芳烃的生物毒性研究甚少。本研究的主要课题是研究来源于大气污染物的多环芳烃混合物对体外人支气管上皮细胞的毒性作用和炎症作用。结果表明，多环芳烃混合物可降低细胞活力，增加细胞凋亡率，并诱导细胞周期停滞在 S 期。此外，多环芳烃混合物处理的细胞中炎症因子 IL-1β和 IL-6 的表达增加，NF-κB 信号通路被激活。本研究的结果表明，多环芳烃混合物诱导的细胞毒性和炎症可能与细胞内 ROS 的产生和激活的 NF-κB 信号通路有关。
