Department of Psychiatry, Center for the Study and Prevention of Suicide, University of Rochester Medical Center, Rochester, NY, USA.
School of Social Work, The University of Texas at Arlington, Arlington, TX, USA.
J Asthma. 2022 Jun;59(6):1122-1130. doi: 10.1080/02770903.2021.1910296. Epub 2021 Apr 14.
The objectives of this cross-sectional study were to examine: 1) the association between adverse childhood experiences (ACEs) and asthma among children, and 2) the interaction between sex and race/ethnicity on asthma.
Data for this study were obtained from the 2017-2018 National Survey of Children's Health. Binary logistic regression was conducted on an analytic sample of 49,000 children ages 0-17 years with asthma as the outcome variable and ACEs as the main explanatory variable.
Based on parent reports, we found that 11.5% of children had asthma and about 42% had at least one ACE, with 9.7% having ≥3 ACEs. Controlling for other factors, children with ≥3 ACEs had 1.45 times higher odds of having asthma when compared to children with no ACEs. Non-Hispanic Black males and females were more likely to have asthma when compared to non-Hispanic White males.
The findings of this study demonstrate an association between ACEs and asthma with children exposed to ≥3 ACEs more likely to have asthma underscoring the importance of cumulative effect of ACEs on asthma. Our study also revealed an interaction between sex and race/ethnicity on asthma among children. Additional studies are needed to understand the mechanisms through which ACEs is associated with asthma among children.
本横断面研究旨在检验：1）儿童不良童年经历（ACEs）与哮喘之间的关系，以及 2）性别和种族/民族对哮喘的交互作用。
本研究数据来自 2017-2018 年全国儿童健康调查。对患有哮喘的 49000 名 0-17 岁儿童的分析样本进行二元逻辑回归分析，将 ACEs 作为主要解释变量，哮喘作为因变量。
根据父母报告，我们发现 11.5%的儿童患有哮喘，约 42%的儿童至少有一种 ACE，其中 9.7%的儿童有≥3 种 ACE。在控制其他因素后，与没有 ACE 的儿童相比，有≥3 种 ACE 的儿童患哮喘的几率高 1.45 倍。与非西班牙裔白人男性相比，非西班牙裔黑人男性和女性更有可能患哮喘。
本研究结果表明 ACEs 与哮喘之间存在关联，暴露于≥3 种 ACEs 的儿童更有可能患哮喘，这突显了 ACEs 对哮喘的累积效应的重要性。我们的研究还揭示了儿童哮喘中性别和种族/民族之间的交互作用。需要进一步的研究来了解 ACEs 与儿童哮喘之间的关联机制。
