正常、泌乳和肿瘤大鼠乳腺组织中碱性磷酸酶活性的比较。
Comparison of alkaline phosphatase activity in normal, lactating and neoplastic rat mammary tissue.
作者信息
Colston K W, Hadcocks L, Cleeve H J
机构信息
Department of Clinical Pathology, St George's Hospital Medical School, London, UK.
出版信息
Comp Biochem Physiol B. 1988;89(4):709-13. doi: 10.1016/0305-0491(88)90312-4.
PMID:3378409
Abstract
- Alkaline phosphatase activity in NMU-induced rat mammary tumours was compared with activity in normal and lactating mammary gland. 2. Both tumour and normal mammary alkaline phosphatase were sensitive to heat inactivation and inhibition by phenylalanine. 3. Specific activity of enzyme in tumours was comparable to normal mammary tissue. 4. Mammary gland alkaline phosphatase increased markedly in late pregnancy and early lactation. 5. Bromocryptine treatment had no effect on enzyme activity in lactating mammary gland.
摘要
- 将NMU诱导的大鼠乳腺肿瘤中的碱性磷酸酶活性与正常和泌乳乳腺中的活性进行了比较。2. 肿瘤和正常乳腺碱性磷酸酶对热失活和苯丙氨酸抑制均敏感。3. 肿瘤中酶的比活性与正常乳腺组织相当。4. 乳腺碱性磷酸酶在妊娠后期和泌乳早期显著增加。5. 溴隐亭治疗对泌乳乳腺中的酶活性没有影响。
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