对重氮烷基脲（Germall II）的接触性过敏。
Contact allergy to diazolidinyl urea (Germall II).
作者信息
de Groot A C, Bruynzeel D P, Jagtman B A, Weyland J W
机构信息
Department of Dermatology, Carolus & Willem-Alexander Hospital, Hertogenbosch, The Netherlands.
出版信息
Contact Dermatitis. 1988 Apr;18(4):202-5. doi: 10.1111/j.1600-0536.1988.tb02803.x.
4 cases of contact allergy to diazolidinyl urea (Germall II) in a "hypoallergenic" brand of cosmetics are described. 2 patients sensitized by these cosmetics were not allergic to formaldehyde. 2 other patients already sensitive to formaldehyde had exacerbations of dermatitis due to diazolidinyl urea. The following tentative conclusions were drawn. (i) Contact allergy to diazolidinyl urea may or may not be due to formaldehyde sensitivity. (ii) Patients allergic to formaldehyde may suffer contact allergic reactions from the use of cosmetics containing diazolidinyl urea. (iii) Patients sensitized to diazolidinyl urea may cross-react to imidazolidinyl urea and vice-versa. (iv) It is suggested that the sensitizing potential of diazolidinyl urea is greater than that of imidazolidinyl urea. (v) Aq. solutions may be preferable to pet. for patch testing with diazolidinyl urea.
本文描述了4例在一个“低敏”品牌化妆品中对双咪唑烷基脲（Germall II）发生接触性过敏的病例。2例因这些化妆品致敏的患者对甲醛不过敏。另外2例已对甲醛敏感的患者因双咪唑烷基脲而使皮炎加重。得出了以下初步结论。（i）对双咪唑烷基脲的接触性过敏可能与甲醛敏感性有关，也可能无关。（ii）对甲醛过敏的患者使用含双咪唑烷基脲的化妆品可能会发生接触性过敏反应。（iii）对双咪唑烷基脲致敏的患者可能与咪唑烷基脲发生交叉反应，反之亦然。（iv）提示双咪唑烷基脲的致敏潜力大于咪唑烷基脲。（v）用双咪唑烷基脲进行斑贴试验时，水溶液可能比凡士林更可取。
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