Metabolic changes in the arterial wall and endothelial injury in experimental methioninaemia.

Chronic administration of methionine to rats induced endothelial lesion manifested by increased endothelaemia and metabolic changes indicative of pathological processes involving the vessel wall. These changes did not spontaneously return to values observed in control animals. Long-term administration of antiatherosclerotic drugs Pyridinolcarbamate and Phtalazinole II normalized metabolic disorder in the aortic wall and reduced endothelaemia to normal values.