van den Hoogen M W F, Seghers L, Manintveld O C, Roest S, Bekkers J A, den Hoed C M, Minnee R C, de Geus H R H, van Thiel R J, Hesselink D A
Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Department of Pulmonology, Thorax Center, Erasmus MC Transplant Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands.
J Crit Care. 2021 Aug;64:37-44. doi: 10.1016/j.jcrc.2021.03.003. Epub 2021 Mar 13.
All transplant recipients receive tacrolimus, mycophenolate and glucocorticoids and these drugs have many side-effects and drug-drug interactions. Common complications include surgical complications, infections, rejection and acute kidney injury. Infections as CMV and PJP can be prevented with prophylactic treatment. Given the complexity of organ transplant recipients a multi-disciplinary team of intensivists, surgeons, pharmacists and transplant specialists is essential. After heart transplantation a temporary pacemaker is required until the conduction system recovers. Stiffening of the heart and increased cardiac markers indicate rejection. An endomyocardial biopsy is performed via the right jugular vein, necessitating its preservation. For lung transplant patients, early intervention for aspiration is warranted to prevent chronic rejection. Risk of any infection is high, requiring active surveillance and intensive treatment, mainly of fungal infections. The liver is immunotolerant requiring lower immunosuppression. Transplantation surgery is often accompanied by massive blood loss and coagulopathy. Other complications include portal vein or hepatic artery thrombosis and biliary leakage or stenosis. Kidney transplant recipients have a high risk of cardiovascular disease and posttransplant anemia should be treated liberally. After postmortal transplantation, delayed graft function is common and dialysis is continued. Ureteral anastomosis complications can be diagnosed with ultrasound.
所有移植受者均接受他克莫司、霉酚酸酯和糖皮质激素治疗,这些药物有许多副作用和药物相互作用。常见并发症包括手术并发症、感染、排斥反应和急性肾损伤。巨细胞病毒(CMV)和肺孢子菌肺炎(PJP)等感染可通过预防性治疗预防。鉴于器官移植受者情况复杂,由重症监护医生、外科医生、药剂师和移植专家组成的多学科团队至关重要。心脏移植后需要临时起搏器,直到传导系统恢复。心脏变硬和心脏标志物升高表明发生排斥反应。通过右颈静脉进行心内膜活检,需要保护该静脉。对于肺移植患者,有必要对误吸进行早期干预以预防慢性排斥反应。任何感染的风险都很高,需要进行积极监测和强化治疗,主要是针对真菌感染。肝脏具有免疫耐受性,需要较低的免疫抑制。移植手术常伴有大量失血和凝血病。其他并发症包括门静脉或肝动脉血栓形成以及胆漏或胆管狭窄。肾移植受者患心血管疾病的风险很高,移植后贫血应积极治疗。死后移植后,移植肾功能延迟恢复很常见,需要继续进行透析。输尿管吻合口并发症可通过超声诊断。