Service d'Immunologie et d'Allergologie, Hôpitaux Universitaires de Genève, Geneva, Switzerland.
Novartis Pharma Schweiz AG, Rotkreuz, Switzerland.
Respiration. 2021;100(6):476-487. doi: 10.1159/000514628. Epub 2021 Mar 30.
Severe asthma commonly affects 5-10% of the asthmatic population and accounts for approximately 50% of the overall asthma costs.
This analysis investigated how severe asthma is diagnosed, treated, and managed by specialists and general practitioners (GPs) in Switzerland.
Two surveys, one each among specialists (N = 44) and GPs (N = 153), were conducted to understand their self-perception on diagnosis, treatment, and management of severe asthma.
Fifty-five percent of the specialists felt very confident and 43% confident in recognizing the symptoms of severe asthma and diagnosing severe asthma. In contrast, 9% of the GPs were very confident and 59% confident in diagnosing severe asthma. More specific diagnostic tests for severe asthma, like total and specific immunoglobulin E levels and measurement of the fraction of exhaled nitric oxide, were run by specialists (χ2 = 171.4; df = 15, p < 0.001). GPs and specialists were using different measurements to assess severe asthma (χ2 = 385.2; df = 13, p < 0.001) and their prescribing patterns differed significantly (χ2 = 189.8; df = 10, p < 0.001). GPs referred patients with severe asthma if the diagnosis was unclear (24%), if treatment failure occurred (26%), and if the patients were at high risk (41%).
Oral corticosteroids (OCSs) are considered as background therapy for severe asthma by GPs and specialists. In order to reduce the OCS burden, there is a need to improve the awareness for other add-on therapies. A joint collaboration between GPs and specialists is the key to leverage therapeutic strategies together.
重度哮喘通常影响哮喘患者的 5-10%,占哮喘总费用的约 50%。
本分析研究了瑞士的专家和全科医生(GP)如何诊断、治疗和管理重度哮喘。
对专家(N=44)和 GP(N=153)进行了两项调查,以了解他们对重度哮喘的诊断、治疗和管理的自我认知。
55%的专家对识别重度哮喘的症状和诊断重度哮喘非常有信心,而 43%的专家有信心。相比之下,9%的 GP 对诊断重度哮喘非常有信心,而 59%的 GP 有信心。更具体的重度哮喘诊断测试,如总免疫球蛋白 E 和特异性免疫球蛋白 E 水平以及呼出气一氧化氮分数的测量,由专家进行(χ2=171.4;df=15,p<0.001)。GP 和专家使用不同的测量方法来评估重度哮喘(χ2=385.2;df=13,p<0.001),他们的处方模式也有显著差异(χ2=189.8;df=10,p<0.001)。GP 将转诊重度哮喘患者,包括诊断不明确(24%)、治疗失败(26%)和患者处于高风险(41%)。
口服皮质类固醇(OCS)被 GP 和专家视为重度哮喘的基础治疗。为了减少 OCS 的负担,需要提高对其他附加治疗的认识。GP 和专家之间的合作是共同利用治疗策略的关键。