Department of Radiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Department of Radiology, The First People's Hospital of Changde City, Changde, Hunan, China.
Sci Rep. 2021 Mar 30;11(1):7183. doi: 10.1038/s41598-021-86695-0.
We used cardiac magnetic resonance tissue tracking (CMR-TT) to quantitatively analyze the global, regional and layer-specific strain of isolated left ventricular noncompaction (ILVNC). Combined with late gadolinium enhancement (LGE), we initially explored the effect of focal myocardial fibrosis on myocardial strain. CMR was performed in 63 patients with ILVNC and 52 patients without ILVNC (i.e., the control group). The ILVNC group was divided into an LGE(+) group (29 patients) and an LGE(-) group (34 patients) according to the presence or absence of late gadalinum enhancement (LGE). CVI42 software was used to measure global and regional (basal, middle, apical) radial strain (RS), circumferential strain (CS), longitudinal strain (LS), subendocardial LS and subepicardial LS. The basal-apical strain gradient was defined as the apical mean strain minus the basal mean strain. We then compared differences between these strain parameters. The subendocardial-subepicardial LS gradient was defined as the maximum subendocardial LS minus the subepicardial LS. Compared with the control group, the global and regional RS, CS, LS and the subendocardial, subepicardial LS of the ILVNC group were significantly diminished (P < 0.01). Compared with the LGE(-) group, the global and regional RS, CS, LS and the subendocardial, subepicardial LS of the LGE(+) group were significantly diminished (P < 0.05). In the ILVNC group, the basal-apical CS and LS gradient, and the subendocardial-subepicardial LS gradient were significantly lower than those in the control group (P < 0.01). There were significant differences in myocardial strain between patients with and without ILVNC. ILVNC revealed a specific pattern in terms of strain change. The myocardial strain of the cardiac apex and endocardium was significantly lower than that of the cardiac base and epicardium, respectively. Myocardial strain reduction was more significant in ILVNC patients with focal myocardial fibrosis.
我们使用心脏磁共振组织追踪（CMR-TT）定量分析孤立性左心室心肌致密化不全（ILVNC）的整体、局部和分层应变。结合晚期钆增强（LGE），我们初步探讨了局灶性心肌纤维化对心肌应变的影响。在 63 例 ILVNC 患者和 52 例无 ILVNC 患者（即对照组）中进行 CMR。根据是否存在晚期钆增强（LGE），将 ILVNC 组分为 LGE(+)组（29 例）和 LGE(-)组（34 例）。使用 CVI42 软件测量整体和局部（基底、中部、心尖）径向应变（RS）、环向应变（CS）、纵向应变（LS）、心内膜下 LS 和心外膜下 LS。基底-心尖应变梯度定义为心尖平均应变减去基底平均应变。然后比较这些应变参数之间的差异。心内膜下心外膜 LS 梯度定义为最大心内膜下 LS 减去心外膜下 LS。与对照组相比，ILVNC 组的整体和局部 RS、CS、LS 以及心内膜下、心外膜下 LS 明显降低（P<0.01）。与 LGE(-)组相比，LGE(+)组的整体和局部 RS、CS、LS 以及心内膜下、心外膜下 LS 明显降低（P<0.05）。在 ILVNC 组，基底-心尖 CS 和 LS 梯度以及心内膜下心外膜 LS 梯度明显低于对照组（P<0.01）。有和没有 ILVNC 的患者之间的心肌应变存在显著差异。ILVNC 在应变变化方面表现出特定的模式。心尖和心内膜的心肌应变明显低于心底部和心外膜，心肌应变降低在伴有局灶性心肌纤维化的 ILVNC 患者中更为显著。
