Weir G C, Bonner-Weir S
Section on Islet Cell and Regenerative Biology, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
CellR4 Repair Replace Regen Reprogram. 2021;9. doi: 10.32113/cellr4_20213_3083. Epub 2021 Mar 16.
There are strong reasons to say that pancreatic islets are organs before they are isolated and that they should be considered to be organs once transplanted. Thus, taking into account how much we have learned about the structure and function of islet micro-organs, it seems highly illogical to on one hand consider autologous islets be regulated as organ transplants and alloislets to be regulated with the very restrictive rules used for cell transplantation. It is particularly problematic that this policy has led to restrictions that have made it next to impossible for transplants of alloislets to be carried out in the US, which is a very sad situation for the country that made so many of the advances that brought islet transplantation to the clinic.
有充分理由表明，胰岛在被分离之前就是器官，并且一旦移植就应被视为器官。因此，考虑到我们对胰岛微器官的结构和功能已经了解了多少，一方面将自体胰岛作为器官移植来管理，而将异体胰岛按照用于细胞移植的非常严格的规则来管理，这似乎极不合理。特别成问题的是，这一政策导致了诸多限制，使得在美国几乎不可能进行异体胰岛移植，对于在胰岛移植临床应用方面取得诸多进展的美国来说，这是非常可悲的情况。
