Kinoshita K, Satake S, Matsui Y, Arai H
Shosuke Satake, Section of Frailty Prevention, Department of Frailty Research, Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, 7-430, Morioka-cho, Obu, Aichi 474-8511, Japan, Phone: +81-0562-46-2311; Fax: +81-0562-46-2373; Email:
J Nutr Health Aging. 2021;25(4):501-506. doi: 10.1007/s12603-020-1557-3.
To investigate the association of three muscle mass adjustment methods with low muscle strength (MS) and low physical function (PF) defined by the Asian Working Group for Sarcopenia (AWGS) 2019 criteria.
Cross-sectional study.
Clinical setting.
We included 361 outpatients (77.9 ± 5.9 years) without scheduled orthopedic surgery or activities of daily living disability.
Appendicular skeletal muscle mass (ASM) was measured by dual-energy X-ray absorptiometry, then divided by height-square (ht2), body weight, and body mass index (BMI) to calculate the ASM indexes. We assessed grip strength, gait speed, short physical performance battery, and five-time chair stand test. Low MS and low PF were defined by the AWGS2019 criteria. To compare the association of three muscle mass adjustments with low MS and low PF, multiple logistic regression analysis was performed, adjusted for age in each sex.
Participants with low MS was 31.5%, low PF was 50.1%. After adjustment, only ASM/BMI was significantly associated with all independent variables, such as low MS, low PF, and either of these, with the odds ratios of 2.09, 2.08, and 2.50 for males; and 1.87, 2.43, and 2.71 for females, respectively.
Our findings suggest that ASM/BMI is best associated with low MS and low PF in older Japanese outpatients. Longitudinal outcome studies are needed to confirm our findings.
探讨三种肌肉量调整方法与根据亚洲肌少症工作组（AWGS）2019标准定义的低肌肉力量（MS）和低身体功能（PF）之间的关联。
横断面研究。
临床环境。
我们纳入了361名门诊患者（77.9±5.9岁），他们没有计划进行骨科手术或日常生活活动障碍。
通过双能X线吸收法测量四肢骨骼肌量（ASM），然后除以身高平方（ht2）、体重和体重指数（BMI）以计算ASM指数。我们评估了握力、步速、简短身体功能测试和五次起坐试验。低MS和低PF根据AWGS2019标准定义。为了比较三种肌肉量调整与低MS和低PF之间的关联，进行了多因素逻辑回归分析，并按性别对年龄进行了调整。
低MS的参与者为31.5%，低PF的参与者为50.1%。调整后，只有ASM/BMI与所有自变量显著相关，如低MS、低PF以及两者之一；男性的比值比分别为2.09、2.08和2.50；女性的比值比分别为1.87、2.43和2.71。
我们的研究结果表明，在日本老年门诊患者中，ASM/BMI与低MS和低PF的关联最为密切。需要进行纵向结局研究来证实我们的发现。
