Medicine Service, VA Medical Center, 700 19th St S, Birmingham, Alabama, 35233, United States.
Department of Medicine at School of Medicine, University of Alabama at Birmingham, 510 20th Street South, Birmingham, AL, 35294, United States.
Clin Rheumatol. 2021 Jul;40(7):3007-3014. doi: 10.1007/s10067-021-05715-6. Epub 2021 Mar 30.
Musculoskeletal diseases (MSDs) are common in the general population, frequently associated with pain, functional limitation, and reduction in quality of life. Similarly, drug/substance use disorders are common in the general population. Recently, opioid drug use disorder has gained a lot of attention as a public health problem. To our knowledge, limited data exist regarding the non-opioid drug/substance use disorders in musculoskeletal diseases. This study's objective was to examine the frequency and rates of common drug/substance use disorder hospitalizations in five MSDs, namely gout, osteoarthritis, fibromyalgia, rheumatoid arthritis, and low back pain. This was achieved by using the diagnostic codes for cocaine, hallucinogen, amphetamine, or ASH use disorder hospitalization in five MSDs in the US National Inpatient Sample from 1998 to 2014. Cocaine, hallucinogen, amphetamine, or ASH use disorder hospitalizations per 1 million NIS total hospitalizations for five MSDs in 2013-2014 were as follows, respectively: gout, 10.2, 0.1, 2.8, and 1.5; osteoarthritis, 21.4, 0.4, 5.9, and 7.7; fibromyalgia, 5.5, 0.1, 2.0, and 2.3; rheumatoid arthritis, 8.7, 0.4, 4.5, and 7.7, and low back pain, 16.2, 0.5, 7.3, and 7.5. The frequency and the rate of each drug use disorder hospitalization increased in each of the five MSDs from 1998 to 2014. Key Points • Cocaine or hallucinogen use disorder hospitalization rates increased several-fold in people with MSDs from 1998 to 2014. • Amphetamine and anxiolytic, sedative, or hypnotic (ASH) use disorder hospitalization rates increased 9- to 23-fold vs. 4- to 7-fold, respectively, in people with common MSDs in the USA from 1998 to 2014.
肌肉骨骼疾病（MSD）在普通人群中很常见，常伴有疼痛、功能受限和生活质量下降。同样，药物/物质使用障碍在普通人群中也很常见。最近，阿片类药物使用障碍作为一个公共卫生问题引起了广泛关注。据我们所知，关于肌肉骨骼疾病中非阿片类药物/物质使用障碍的数据有限。本研究的目的是调查五种 MSD（痛风、骨关节炎、纤维肌痛、类风湿关节炎和腰痛）中常见的药物/物质使用障碍住院治疗的频率和发生率。这是通过使用美国国家住院患者样本 1998 年至 2014 年五种 MSD 中可卡因、致幻剂、安非他命或苯二氮䓬使用障碍住院治疗的诊断代码来实现的。2013-2014 年，每 100 万 NIS 五种 MSD 总住院人数中可卡因、致幻剂、安非他命或苯二氮䓬使用障碍住院人数分别为：痛风 10.2、0.1、2.8 和 1.5；骨关节炎 21.4、0.4、5.9 和 7.7；纤维肌痛 5.5、0.1、2.0 和 2.3；类风湿关节炎 8.7、0.4、4.5 和 7.7；腰痛 16.2、0.5、7.3 和 7.5。从 1998 年到 2014 年，每种药物使用障碍住院治疗的频率和比率在五种 MSD 中均有所增加。主要发现 • 1998 年至 2014 年，患有 MSD 的人群中可卡因或致幻剂使用障碍住院率增加了数倍。 • 1998 年至 2014 年，美国常见 MSD 患者的安非他命和苯二氮䓬（苯二氮䓬）使用障碍住院率分别增加了 9 至 23 倍和 4 至 7 倍。
