Milanesio Martin, Suasnabar David Francisco, Giaj-Merlera Alejandro, Cebreros Rocío Gabriela, Marucco Federico Ariel
Hospital Privado Universitario de Córdoba.
Hospital Raúl Ángel Ferreyra.
Rev Fac Cien Med Univ Nac Cordoba. 2021 Mar 12;78(1):64-67. doi: 10.31053/1853.0605.v78.n1.30818.
COVID-19 disease is an acute viral pneumonia with multiple extrapulmonary manifestations, including certain hematological alterations. The leukoerythroblastic reaction or leukoerythroblastosis is defined by the presence in peripheral blood of nucleated erythroid cells and immature myeloids. Among its most frequent causes is medullary invasion by solid tumors and hematological neoplasms, so the recognition and consequent study of this reaction is extremely important. To date, only a single case of COVID-19 disease associated with a leukoerythroblastic reaction has been reported worldwide in adult patients.
In the following manuscript we describe the presence of leukoerythroblastosis in a male hospitalized for COVID-19, in which multiple causes were ruled out.
The patient had resolution of the leukoerythroblatosis as his respiratory symptoms resolved.
The COVID-19 disease could be a new known cause of a leukoerythroblastic reaction, although we believe that a greater number of reported cases is necessary to affirm that the association was not random.
新型冠状病毒肺炎(COVID-19)是一种急性病毒性肺炎,伴有多种肺外表现,包括某些血液学改变。幼粒-幼红细胞反应或幼粒-幼红细胞增多症的定义是外周血中出现有核红细胞和未成熟髓细胞。其最常见的原因包括实体瘤和血液系统肿瘤的骨髓浸润,因此识别并随后研究这种反应极为重要。迄今为止,全球仅报道了1例成年COVID-19患者伴有幼粒-幼红细胞反应。
在以下手稿中,我们描述了1例因COVID-19住院的男性患者出现幼粒-幼红细胞增多症的情况,其中排除了多种病因。
随着呼吸症状的缓解,该患者的幼粒-幼红细胞增多症也得到了缓解。
COVID-19可能是幼粒-幼红细胞反应的一个新的已知病因,尽管我们认为需要更多的报道病例才能确定这种关联并非偶然。