Ma Jin-Jin, Ying Jun, Duan Xiao-Hong, Xiao Lu-Wei, Jin Hong-Ting, Feng Jian-Ying
School of Stomatology, Zhejiang Chinese Medical University, Hangzhou 310053, Zhejiang, China.
Zhongguo Gu Shang. 2021 Mar 25;34(3):265-8. doi: 10.12200/j.issn.1003-0034.2021.03.015.
Osteoporosis is one of the common clinical orthopedic diseases, which can lead to a variety of complications. There are many pathogenic factors in this disease. The latest research found that ATP6V1H is a new gene leading to the occurrence of osteoporosis, and it is likely to become a new target for the future drug treatment of osteoporosis.This paper introduces the biological structure and characteristics of H subunit, summed up the human body caused by loss of ATP6V1H and animal models such as zebrafish, mice bone loss and osteoporosis symptom such as related research reports of the loss, from osteoclast, osteoblast and marrow stromal cell level and the connection between the various subunits further expounds the H subunit regulate bone dynamic balance of mechanism, to explore ATP6V1H in bone developmentand bone related diseases has laid a solid foundation, also provide new ideas for clinical treatment of osteoporosis.
骨质疏松症是临床常见的骨科疾病之一，可导致多种并发症。该疾病存在多种致病因素。最新研究发现，ATP6V1H是导致骨质疏松症发生的一个新基因，且很可能成为未来骨质疏松症药物治疗的新靶点。本文介绍了H亚基的生物学结构与特性，总结了人体因ATP6V1H缺失以及斑马鱼、小鼠等动物模型骨量丢失和骨质疏松症状等相关研究报道中有关缺失的情况，从破骨细胞、成骨细胞和骨髓基质细胞水平以及各亚基之间的联系进一步阐述了H亚基调节骨动态平衡的机制，为探索ATP6V1H在骨骼发育及骨相关疾病方面奠定了坚实基础，也为骨质疏松症的临床治疗提供了新思路。
