School of Chemistry and Materials Science, Heilongjiang University, Harbin 150080, P.R. China.
Org Lett. 2021 Apr 16;23(8):2868-2872. doi: 10.1021/acs.orglett.1c00468. Epub 2021 Mar 31.
A nickel-catalyzed C-H cyanation reaction of arenes has been developed using 2-cyanoisothiazolidine 1,1-dioxide as an electrophilic cyanation reagent. Many different directing groups can be used in this cyanation to obtain a series of cyanation products with good yields. Adopting this strategy to introduce a cyano group, natural alkaloid menisporphine was successfully synthesized through cyano group conversion that further proved the practicality of this cyanation method.
镍催化芳环的 C-H 氰化反应已经发展起来，使用 2-氰基异噻唑啉 1,1-二氧化物作为亲电氰化试剂。在这种氰化反应中可以使用许多不同的导向基团，以获得一系列产率良好的氰化产物。采用这种策略引入氰基，通过氰基转化成功合成了天然生物碱麦斯朋，进一步证明了这种氰化方法的实用性。
