Komorowski R A, Hanson G A
Department of Pathology, Medical College of Wisconsin, Milwaukee 53226.
Hum Pathol. 1988 Jun;19(6):689-96. doi: 10.1016/s0046-8177(88)80175-8.
Thyroid glands from autopsies on 138 adults, ages 20 to 40 years, with no known clinical or laboratory evidence of thyroid disease, were serially sectioned at 2 mm intervals and microscopically examined for occult thyroid disease and anatomic variations. Occult papillary carcinoma was found in 3% of the glands, along with a single case of medullary carcinoma. The prevalence of occult thyroid carcinoma in this group of young adults is significantly less than that reported in the literature in people over forty (P less than .001). The glands demonstrated a number of other morphologic changes of importance to surgical pathologists. The thyroid capsule was incomplete in 62% of the glands. Thyroid follicles were found in the capsule in 14% of cases and thyroid follicles or nodules were outside the gland in perithyroid connective tissue in 88% of cases. Thyroid follicles were identified in 7% of cases in perithyroid strap muscles attached to the pyramidal lobe. A number of other, less common anatomic variations were also seen.
对138名年龄在20至40岁之间、无已知甲状腺疾病临床或实验室证据的成年人进行尸检，获取甲状腺，每隔2毫米连续切片，并进行显微镜检查，以查找隐匿性甲状腺疾病和解剖变异。在3%的腺体中发现了隐匿性乳头状癌，还有1例髓样癌。该组年轻成年人中隐匿性甲状腺癌的患病率显著低于四十岁以上人群的文献报道（P小于0.001）。这些腺体还表现出一些对外科病理学家来说很重要的其他形态学变化。62%的腺体甲状腺包膜不完整。14%的病例在包膜中发现甲状腺滤泡，88%的病例在甲状腺周围结缔组织中的腺体外发现甲状腺滤泡或结节。在附着于锥体叶的甲状腺周围带状肌中，7%的病例发现了甲状腺滤泡。还观察到一些其他不太常见的解剖变异。
