I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
Bull Exp Biol Med. 2021 Mar;170(5):618-622. doi: 10.1007/s10517-021-05118-2. Epub 2021 Mar 31.
Glucagon-like peptide-1 (GLP-1), a product of partial proteolysis of proglucagon, is involved not only in regulation of carbohydrates, but also in water-salt metabolism. The study examined the role of proglucagon derivatives GLP-1, GLP-2, and oxyntomodulin in rat osmoregulation. Of them, only blood plasma GLP-1 increased in response to water load (20 ml/kg). Administration of glucose (1.5 g/kg) elevated GLP-1 and oxyntomodulin but did not change the level of GLP-2. GLP-1 accelerated excretion of excess water during hyperhydration, whereas GLP-2 decreased this parameter. No physiological effects of oxyntomodulin in the kidneys were revealed. Probably, the blood levels of proglucagon derivatives are independently regulated for each peptide. In contrast to GLP-2 and oxyntomodulin, GLP-1 is involved in osmoregulation.
胰高血糖素样肽-1（GLP-1）是胰高血糖素原部分水解的产物，不仅参与碳水化合物的调节，还参与水盐代谢。本研究探讨了胰高血糖素原衍生物 GLP-1、GLP-2 和胰高血糖素样肽-2 在大鼠渗透压调节中的作用。其中，只有血 GLP-1 对水负荷（20ml/kg）有反应性增加。给予葡萄糖（1.5g/kg）可升高 GLP-1 和胰高血糖素样肽-2，但不改变 GLP-2 水平。GLP-1 可加速水负荷时多余水分的排泄，而 GLP-2 则降低这一参数。在肾脏中未发现胰高血糖素样肽-2 的生理作用。可能，每种肽的胰高血糖素原衍生物的血液水平是独立调节的。与 GLP-2 和胰高血糖素样肽-2 不同，GLP-1 参与渗透压调节。
