Department of Urology, Gyeongsang National University Hospital, Jinju, Republic of Korea.
Department of Urology, College of Medicine, Gyeongsang National University, Jinju, Republic of Korea.
Anticancer Res. 2021 Mar;41(3):1377-1386. doi: 10.21873/anticanres.14895.
BACKGROUND/AIM: The purpose of this study was to examine the expression of estrogen receptor α (ERα) and β (ERβ), androgen receptor (AR), SIRT1, SIRT2 and SIRT3 in prostate cancer (PCa).
From October 2010 to January 2015, 70 patients who had undergone radical prostatectomy following a PCa diagnosis were enrolled in our study. Normal prostate tissue (NPT) and prostate cancer tissues (PCAT) were separated, and the expression of each receptor in each tissue was analyzed with immunochemical staining. Univariate and multivariate analyses were performed to identify factors affecting the development of PCa.
ERβ and AR were highly expressed in PCAT compared with NPT (p<0.05). SIRT2 was highly expressed in NPT and PCAT (p<0.05). Univariate and multivariate analyses showed that AR and SIRT2 affect PCa development.
AR is a risk factor for PC, and SIRT2 is associated with a lower incidence of PCa.
背景/目的：本研究旨在检测前列腺癌（PCa）中雌激素受体α（ERα）和β（ERβ）、雄激素受体（AR）、SIRT1、SIRT2 和 SIRT3 的表达。
本研究纳入了 2010 年 10 月至 2015 年 1 月期间因 PCa 接受根治性前列腺切除术的 70 例患者。分离正常前列腺组织（NPT）和前列腺癌组织（PCAT），并用免疫化学染色分析每种组织中每种受体的表达。进行单变量和多变量分析，以确定影响 PCa 发展的因素。
与 NPT 相比，PCAT 中 ERβ 和 AR 的表达较高（p<0.05）。SIRT2 在 NPT 和 PCAT 中高表达（p<0.05）。单变量和多变量分析表明，AR 和 SIRT2 影响 PCa 的发展。
AR 是 PC 的危险因素，而 SIRT2 与 PCa 的发生率较低相关。
