Oncology Unit, 3 Department of Medicine, "Sotiria" General Hospital, Schoolof Medicine, National and Kapodistrian University of Athens, Athens, Greece
Oncology Unit, 3 Department of Medicine, "Sotiria" General Hospital, Schoolof Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Anticancer Res. 2021 Mar;41(3):1523-1528. doi: 10.21873/anticanres.14911.
BACKGROUND/AIM: Small cell lung cancer (SCLC) accounts for 13% of all lung cancers. Venous thromboembolism (VTE) is a frequent complication. The purpose of this study was to investigate the incidence and risk factors for VTE in SCLC patients.
Retrospective analysis of patients with histologically confirmed SCLC treated between January 2015 and June 2018 at Sotiria General Hospital, Athens, Greece.
Two hundred and seventeen patients were included in the analysis. The incidence of VTE was 4.1%. Increased body mass index (BMI) was correlated with the development of VTE. Moreover, VTE appeared more frequently in patients with major vessel infiltration and with poor Eastern Cooperative Oncology Group Performance Status. Other factors, including gender, age, stage, presence of metastasis, treatment, immobilization, anticoagulation, comorbidities, and laboratory values did not correlate with the development of VTE.
Factors associated with the development of VTE were BMI, major vessel infiltration and PS. Identifying factors that predispose to VTE could help physicians detect high-risk patients who would benefit from prophylactic anticoagulation therapy.
背景/目的：小细胞肺癌（SCLC）约占所有肺癌的 13%。静脉血栓栓塞症（VTE）是一种常见的并发症。本研究旨在探讨 SCLC 患者 VTE 的发生率和危险因素。
回顾性分析了 2015 年 1 月至 2018 年 6 月在希腊雅典 Sotiria 综合医院接受治疗的经组织学证实的 SCLC 患者。
共纳入 217 例患者进行分析。VTE 的发生率为 4.1%。体重指数（BMI）增加与 VTE 的发生相关。此外，大血管浸润和东部合作肿瘤学组（ECOG）表现状态差的患者 VTE 更常见。其他因素，包括性别、年龄、分期、转移、治疗、固定、抗凝、合并症和实验室值与 VTE 的发生无关。
与 VTE 发生相关的因素是 BMI、大血管浸润和 PS。确定易发生 VTE 的因素有助于医生发现高危患者，这些患者可能受益于预防性抗凝治疗。
