Department of Gastroenterological Surgery, Hyogo College of Medicine, Nishinomiya, Japan;
Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan.
Anticancer Res. 2021 Mar;41(3):1571-1577. doi: 10.21873/anticanres.14917.
BACKGROUND/AIM: Tumor-infiltrating Foxp3 regulatory T-cells (Ti-Tregs) promote tumor progression and contribute to poor prognosis in gastric cancer, but the relationship between Ti-Tregs and response to chemotherapy for liver metastases from gastric cancer (LMGC) is unclear. We estimated the correlation between pathological response to chemotherapy and Ti-Tregs in LMGC.
Ti-Tregs were analyzed with immunohistochemistry as CD3 Foxp3 cells in patients with synchronous LMGC.
Of 53 patients with LMGC, 49 received chemotherapy as initial treatment and 10 underwent R0 resection. LMGC disappeared pathologically in 5 resected cases despite radiologically residual disease. Ti-Tregs were found frequently in residual LMGC and primary lesions but rarely in tumor scar tissue. There was no relationship between frequency of CD8 cells and pathological response.
Marked reduction in Ti-Tregs correlates with pathological complete remission of LMGC. Ti-Tregs may be a biomarker to predict the effects of chemotherapy when used in combination with radiological findings.
背景/目的：肿瘤浸润性 Foxp3 调节性 T 细胞（Ti-Tregs）促进肿瘤进展，并与胃癌的预后不良相关，但 Ti-Tregs 与胃癌肝转移（LMGC）化疗反应之间的关系尚不清楚。我们评估了 LMGC 化疗病理反应与 Ti-Tregs 之间的相关性。
采用免疫组织化学法分析同步 LMGC 患者的 Ti-Tregs，以 CD3 Foxp3 细胞表示。
53 例 LMGC 患者中，49 例接受化疗作为初始治疗，10 例行 R0 切除术。尽管影像学上仍有残留病灶，但在 5 例切除的病例中，LMGC 病理上消失。在残留的 LMGC 和原发性病变中经常发现 Ti-Tregs，但在肿瘤瘢痕组织中很少发现。CD8 细胞的频率与病理反应之间无相关性。
Ti-Tregs 的明显减少与 LMGC 的病理完全缓解相关。Ti-Tregs 可能是一种生物标志物，与影像学发现结合使用时可预测化疗效果。
