胃癌肝转移的病理完全缓解与肿瘤浸润性 Tregs 的消除相关。

Pathological Complete Remission of Liver Metastases Correlates With Elimination of Tumor-infiltrating Tregs in Gastric Cancer.

机构信息

Department of Gastroenterological Surgery, Hyogo College of Medicine, Nishinomiya, Japan;

Department of Surgical Pathology, Hyogo College of Medicine, Nishinomiya, Japan.

出版信息

Anticancer Res. 2021 Mar;41(3):1571-1577. doi: 10.21873/anticanres.14917.

DOI:10.21873/anticanres.14917

PMID:33788751

Abstract

BACKGROUND/AIM: Tumor-infiltrating Foxp3 regulatory T-cells (Ti-Tregs) promote tumor progression and contribute to poor prognosis in gastric cancer, but the relationship between Ti-Tregs and response to chemotherapy for liver metastases from gastric cancer (LMGC) is unclear. We estimated the correlation between pathological response to chemotherapy and Ti-Tregs in LMGC.

PATIENTS AND METHODS

Ti-Tregs were analyzed with immunohistochemistry as CD3 Foxp3 cells in patients with synchronous LMGC.

RESULTS

Of 53 patients with LMGC, 49 received chemotherapy as initial treatment and 10 underwent R0 resection. LMGC disappeared pathologically in 5 resected cases despite radiologically residual disease. Ti-Tregs were found frequently in residual LMGC and primary lesions but rarely in tumor scar tissue. There was no relationship between frequency of CD8 cells and pathological response.

CONCLUSION

Marked reduction in Ti-Tregs correlates with pathological complete remission of LMGC. Ti-Tregs may be a biomarker to predict the effects of chemotherapy when used in combination with radiological findings.

摘要

背景/目的：肿瘤浸润性 Foxp3 调节性 T 细胞（Ti-Tregs）促进肿瘤进展，并与胃癌的预后不良相关，但 Ti-Tregs 与胃癌肝转移（LMGC）化疗反应之间的关系尚不清楚。我们评估了 LMGC 化疗病理反应与 Ti-Tregs 之间的相关性。