Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
Anticancer Res. 2021 Mar;41(3):1579-1586. doi: 10.21873/anticanres.14918.
BACKGROUND/AIM: Histological changes induced by neoadjuvant chemotherapy (NAC) have rarely been reported in histological subtypes other than ovarian high-grade serous carcinoma (HGSC).
We report a 49-year-old woman whose tumors in interval debulking surgery (IDS) specimen exhibited prominent papillary growth pattern and severe nuclear pleomorphism due to NAC. In the initial microscopic examination, ovarian HGSC was the most likely candidate; however, immunostaining results were not compatible with HGSC. We detected areas resembling mucinous cystadenoma and borderline tumor, and finally diagnosed this case as ovarian mucinous carcinoma.
Although the tumor mimicked histologically HGSC, its clinical features differed from those of advanced-stage HGSC. It is important for pathologists to recognize NAC-induced histological changes, be aware of the diagnostic mimics and pitfalls, and to identify the correct histological subtype by considering the patient's previous history, clinical features, preoperative imaging findings, and histological features.
背景/目的：新辅助化疗（NAC）引起的组织学变化在卵巢高级别浆液性癌（HGSC）以外的组织学亚型中很少见报道。
我们报告了一例 49 岁女性，其间隔减瘤手术（IDS）标本中的肿瘤由于 NAC 而表现出明显的乳头状生长模式和严重的核多形性。在最初的显微镜检查中，卵巢 HGSC 是最有可能的候选者；然而，免疫组化结果与 HGSC 不符。我们检测到类似于黏液性囊腺瘤和交界性肿瘤的区域，最终诊断为卵巢黏液性癌。
尽管肿瘤在组织学上类似于 HGSC，但它的临床特征与晚期 HGSC 不同。病理学家识别 NAC 诱导的组织学变化、了解诊断模拟和陷阱、并通过考虑患者的既往病史、临床特征、术前影像学发现和组织学特征来识别正确的组织学亚型非常重要。
