药物性间质性肺疾病导致的肺癌患者死亡率与老年患者相同。
Drug-induced Interstitial Lung Disease Has the Same Degree of Risk for Mortality as Old Age in Patients With Lung Cancer.
机构信息
Department of Clinical Pharmacy, Fujita Health University School of Medicine, Toyoake, Japan.
Department of Clinical Pharmacy, Fujita Health University School of Medicine, Toyoake, Japan;
出版信息
Anticancer Res. 2021 Mar;41(3):1707-1711. doi: 10.21873/anticanres.14935.
BACKGROUND/AIM: The aim of this study was to investigate the impact of drug-induced interstitial lung disease (DILD) on the mortality of patients with lung cancer.
PATIENTS AND METHODS
Japanese patients with lung cancer who had received chemotherapy in Fujita Health University Hospital from January 2017 to December 2018 were enrolled in this study. The primary outcome was to identify independent factors associated with patient mortality. The secondary outcome was to identify the risk factor of DILD.
RESULTS
Four hundred and fifty-seven patients were assigned to the current study. The multivariable analysis revealed that being aged 75 years or older, small cell lung carcinoma, cancer stage IV, and DILD event were risk factors of mortality. Male sex was identified as a risk factor of DILD.
CONCLUSION
DILD event has the same degree of risk for mortality as age 75 years or older in lung cancer patients.
背景/目的：本研究旨在探讨药物性间质性肺病（DILD）对肺癌患者死亡率的影响。
患者和方法
本研究纳入了 2017 年 1 月至 2018 年 12 月在藤田保健卫生大学医院接受化疗的肺癌日本患者。主要结局是确定与患者死亡率相关的独立因素。次要结局是确定 DILD 的危险因素。
结果
本研究共纳入了 457 名患者。多变量分析显示，年龄 75 岁或以上、小细胞肺癌、癌症分期 IV 期和 DILD 事件是死亡的危险因素。男性是 DILD 的危险因素。
结论
DILD 事件对肺癌患者的死亡率的影响与 75 岁或以上的年龄相当。
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