描述持续性治疗后莱姆病症状患者的症状特征：罗德岛莱姆病诊所患者的一项调查。

Characterizing the Symptoms of Patients with Persistent Post-Treatment Lyme Symptoms: A Survey of Patients at a Lyme Disease Clinic in Rhode Island.

机构信息

Research Scientist, Center for Behavioral and Preventive Medicine, The Miriam Hospital, Providence, RI; Assistant Professor (Research), Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI.

Research Assistant, Division of Infectious Disease, The Miriam Hospital, Providence, RI.

出版信息

R I Med J (2013). 2021 Apr 1;104(3):53-57.

PMID:33789412

Abstract

BACKGROUND

10-20% of individuals diagnosed with Lyme disease develop chronic symptoms after antibiotic treatment.

METHODS

A convenience sample of adults with self- reported, persistent post-Lyme treatment symptoms seeking treatment at the Lifespan Lyme Disease Center in Rhode Island completed a demographic and medical survey, the Patient Reported Outcomes Measurement Information System (PROMIS)-29 v2.0, and other short-form PROMIS measures of cognitive function, sleep disturbance, and fatigue.

RESULTS

Compared to average standardized scale scores (T=50; SD=10), participants had mild impairments in physical (T=41) and social (T=42) functioning, mild symptoms of depression (T=56), anxiety (T=60), and sleep disturbance (T=57), and moderate pain interference (T=62), and fatigue (T=65). Participants reported greater symptoms than some other clinical samples including those with cancer and chronic pain. Post-hoc analyses revealed that women reported higher levels of fatigue than men.

CONCLUSIONS

People with persistent post-Lyme treatment symptoms report debilitating symptoms and functional impairments which must be considered in clinical care.

摘要

背景

10-20%被诊断患有莱姆病的个体在抗生素治疗后会出现慢性症状。

方法

在罗德岛州生命跨度莱姆病中心寻求治疗的、自我报告有持续性莱姆病治疗后症状的成年人中，采用方便抽样法，完成了一份人口统计学和医学调查、患者报告结局测量信息系统（PROMIS）-29 v2.0 以及其他认知功能、睡眠障碍和疲劳的短式 PROMIS 测量。

结果

与平均标准化量表评分（T=50；SD=10）相比，参与者的身体（T=41）和社会（T=42）功能、抑郁症状（T=56）、焦虑（T=60）和睡眠障碍（T=57）轻度受损，疼痛干扰（T=62）和疲劳（T=65）程度中等。参与者报告的症状比其他一些临床样本更严重，包括癌症和慢性疼痛患者。事后分析显示，女性报告的疲劳水平高于男性。