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原发性胆汁性胆管炎中针对斑点蛋白家族的自身抗体。

Autoantibodies to speckled protein family in primary biliary cholangitis.

作者信息

Granito Alessandro, Muratori Luigi, Tovoli Francesco, Muratori Paolo

机构信息

Division of Internal Medicine, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138, Bologna, Italy.

Center for the Study, Treatment of Autoimmune Diseases of the Liver, Biliary System, Bologna, Italy.

出版信息

Allergy Asthma Clin Immunol. 2021 Mar 31;17(1):35. doi: 10.1186/s13223-021-00539-0.

DOI:10.1186/s13223-021-00539-0
PMID:33789734
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8011120/
Abstract

The autoantibody profile of primary biliary cholangitis (PBC) includes antinuclear antibodies (ANA) which are detectable by indirect immunofluorescence in more than 50% of PBC patients. One of the two immunofluorescence patterns which are historically considered "PBC-specific" is the so-called "multiple nuclear dots" (MND) targeting nuclear body proteins such as Sp100, Sp140, Sp140L proteins, promyelocytic leukemia protein (PML) and small ubiquitin-related modifier proteins (SUMO). It has been hypothesized a role of nuclear body protein alterations in immune disorders such as PBC, thus suggesting novel and more refined therapeutic approaches.

摘要

原发性胆汁性胆管炎（PBC）的自身抗体谱包括抗核抗体（ANA），通过间接免疫荧光法可在超过50%的PBC患者中检测到。历史上被认为是“PBC特异性”的两种免疫荧光模式之一是所谓的“多核点”（MND），其靶向核体蛋白，如Sp100、Sp140、Sp140L蛋白、早幼粒细胞白血病蛋白（PML）和小泛素相关修饰蛋白（SUMO）。有人推测核体蛋白改变在诸如PBC等免疫疾病中起作用，从而提示新的、更精细的治疗方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cac6/8011120/2eba6388df18/13223_2021_539_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cac6/8011120/2eba6388df18/13223_2021_539_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cac6/8011120/2eba6388df18/13223_2021_539_Fig1_HTML.jpg

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本文引用的文献

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Trends Immunol. 2020 Jul;41(7):572-585. doi: 10.1016/j.it.2020.04.007. Epub 2020 May 5.
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Pathogen infections and primary biliary cholangitis.病原体感染与原发性胆汁性胆管炎。
Clin Exp Immunol. 2019 Jan;195(1):25-34. doi: 10.1111/cei.13198. Epub 2018 Sep 17.
3
Emerging Role of PML Nuclear Bodies in Innate Immune Signaling.早幼粒细胞白血病核体在天然免疫信号传导中的新作用
原发性胆汁性胆管炎患者循环单核细胞趋化蛋白-1（MCP-1）
Int J Mol Sci. 2024 Jan 22;25(2):1333. doi: 10.3390/ijms25021333.
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Laboratory risk factors for coexistent primary biliary cholangitis in patients with Sjögren's syndrome: a retrospective study.干燥综合征患者原发性胆汁性胆管炎共存的实验室危险因素：一项回顾性研究。
BMC Gastroenterol. 2023 Jun 26;23(1):220. doi: 10.1186/s12876-023-02859-4.
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Aberrant cytokeratin 7 expression by hepatocytes can predict the ductopenia grade in primary biliary cholangitis.肝细胞异常表达细胞角蛋白 7 可预测原发性胆汁性胆管炎的胆管缺失程度。
BMC Gastroenterol. 2022 Nov 2;22(1):443. doi: 10.1186/s12876-022-02538-w.
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PCBP1 is associated with rheumatoid arthritis by affecting RNA products of genes involved in immune response in Th1 cells.PCBP1 通过影响 Th1 细胞中免疫应答相关基因的 RNA 产物而与类风湿关节炎相关。
Sci Rep. 2022 May 19;12(1):8398. doi: 10.1038/s41598-022-12594-7.
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