Maron M B, Pilati C F
Department of Physiology, Northeastern Ohio Universities College of Medicine, Rootstown 44272.
J Appl Physiol (1985). 1988 Apr;64(4):1746-8. doi: 10.1152/jappl.1988.64.4.1746.
The solvent drag reflection coefficient (sigma) for total proteins can be estimated by comparing the relative degrees of concentration of erythrocytes and plasma proteins that occur during fluid filtration in an isolated perfused organ. In this analysis, we evaluated the accuracy of equations proposed by Pilati and Maron [Am. J. Physiol. 247 (Heart Circ. Physiol. 16): H1-H7, 1984] and Wolf et al. [Am. J. Physiol. 253 (Heart Circ. Physiol. 22): H194-H204, 1987] to calculate sigma from these concentration changes. We calculated sigma with each equation using data generated from a mathematical model of fluid and solute flux in membranes with known sigma's. We found that the equation of Wolf et al. provided the closest approximation to the true sigma over the entire range of filtration fractions tested (0.1-0.6), with the differences between the two equations increasing with filtration fraction. At low filtration fractions, the difference in sigma obtained using either approach was found to be inconsequential. At larger filtration fractions, a closer approximation of the true sigma can be obtained using the equation of Wolf et al.
总蛋白的溶剂拖曳反射系数（σ）可通过比较在离体灌注器官的液体滤过过程中红细胞和血浆蛋白的相对浓缩程度来估算。在此分析中，我们评估了皮拉蒂和马龙[《美国生理学杂志》247卷（心脏循环生理学16）：H1 - H7，1984年]以及沃尔夫等人[《美国生理学杂志》253卷（心脏循环生理学22）：H194 - H204，1987年]提出的根据这些浓度变化计算σ的方程的准确性。我们使用具有已知σ值的膜中流体和溶质通量的数学模型生成的数据，用每个方程计算σ。我们发现，在测试的整个滤过分数范围（0.1 - 0.6）内，沃尔夫等人的方程最接近真实的σ，两个方程之间的差异随滤过分数增加。在低滤过分数时，发现使用任何一种方法获得的σ差异都无关紧要。在较大的滤过分数时，使用沃尔夫等人的方程可以更接近真实的σ。
