A Family Case of COVID-19 Pneumonia with Different Chest CT Features and Duration of SARS-CoV-2 Shedding: a Case Report from Japan.

Coronavirus disease 2019 (COVID-19) pneumonia in children characteristically has a milder clinical presentation, with milder inflammatory biomarkers and radiological findings. Accumulating evidence indicates a difference in chest computed tomography (CT) features and the duration of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) shedding between children and adults. Here, we report a family case of COVID-19 pneumonia in which 2 brothers (aged 14 years and 2 years) had different findings. On admission, the 2-year-old brother had few symptoms with no signs of pneumonia, whereas the older brother had presented with pneumonia on admission. Both were positive for SARS-CoV-2 infection on polymerase chain reaction and showed obvious characteristic signs of COVID-19 pneumonia on chest CT. However, CT findings in the younger brother were nonspecific and similar to those of other pneumonias. The older brother required longer treatment because of the longer shedding period of SARS-CoV-2 detected in nasopharyngeal samples. Both boys were discharged without complications. This family case suggests that the clinical features of COVID-19 pneumonia might differ between younger and older children.