比沙可啶抑制 NCI-H292 细胞中 TGF-α诱导的 MUC5AC 产生。
Bisacodyl Suppresses TGF-α-Induced MUC5AC Production in NCI-H292 Cells.
机构信息
Laboratory of Applied Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science.
出版信息
Biol Pharm Bull. 2021;44(4):590-592. doi: 10.1248/bpb.b20-00886.
MUC5AC overproduction is commonly observed in chronic inflammatory lung diseases and worsens these conditions. Therefore, drugs that inhibit MUC5AC production are urgently needed. To identify novel drugs directly inhibiting MUC5AC production, 640 already approved drugs were screened. We found that the laxative bisacodyl suppressed transforming growth factor (TGF)-α-induced MUC5AC production in a concentration-dependent manner. Additionally, bisacodyl also suppressed TGF-α-induced MUC5AC mRNA expression in the same concentration range. These results suggested that bisacodyl could be a new drug for treating mucin overproduction.
MUC5AC 的过度产生在慢性炎症性肺病中很常见，并且会使这些病症恶化。因此，急需能够抑制 MUC5AC 产生的药物。为了鉴定直接抑制 MUC5AC 产生的新型药物，我们筛选了 640 种已批准的药物。我们发现，泻药比沙可啶以浓度依赖的方式抑制转化生长因子 (TGF)-α诱导的 MUC5AC 产生。此外，比沙可啶还在相同浓度范围内抑制 TGF-α诱导的 MUC5AC mRNA 表达。这些结果表明，比沙可啶可能是治疗粘蛋白过度产生的新药。
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