25-羟维生素 D 水平低与中国 2 型糖尿病患者的动脉僵硬有关。
Low 25-hydroxyvitamin D is associated with arterial stiffness in Chinese with Type 2 diabetes mellitus.
机构信息
Department of Endocrinology and Metabolism, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Department of Gastrointestinal Surgery, Tongji University School of Medicine, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China.
出版信息
Eur J Clin Nutr. 2021 Nov;75(11):1645-1653. doi: 10.1038/s41430-021-00870-0. Epub 2021 Mar 31.
OBJECTIVES
Arterial stiffness (AS), one of the complications of diabetes, associated with many metabolic factors. This study aimed to investigate the association between 25-hydroxyvitamin D(25(OH)D) and AS in type 2 diabetes mellitus (T2DM).
METHODS
We identified 1335 diabetic patients from the Department of Endocrinology, Shanghai Tenth People's Hospital. Finally, 603 T2DM patients were included in the study. They were divided into two groups: AS group (baPWV ≥ 15,500 cm/s) and the control group (baPWV < 1550 cm/s).
RESULTS
(1) Heart rate (HR) and systolic pressure (SBP) were higher while body weight and body mass index (BMI) were smaller in AS group than the control group (all P < 0.05). (2) Compared to patients without AS, patients with AS showed lower 25(OH)D and higher rate of 25(OH)D deficiency (42 ± 16 vs. 45 ± 17 mol/l, 68% vs. 64%, all P < 0.05). (3) BaPWV was negatively associated with 25(OH)D (r = -0.12, P = 0.004), while positively associated with age, duration of diabetes, HR, SBP, and low-density lipoprotein cholesterol and negatively associated with body weight and BMI (all P < 0.05). (4) Multiple linear regression showed that 25(OH)D was the negatively influencing factor of baPWV (β = -2.2, P = 0.01). Logistic regression showed that age and SBP were risk factor of AS (OR:1.07, 95% CI: 1.05-1.10, P < 0.001; OR:1.03, 95% CI: 1.02-1.04, P < 0.001) while 25(OH)D was protective factor of AS (OR:0.987, 95% CI: 0.976-0.998, P = 0.024).
CONCLUSIONS
T2DM patients with AS had lower 25(OH)D and higher rate of 25(OH)D deficiency. There was a negative relationship between 25(OH)D and AS assessed by baPWV.
目的
动脉僵硬度（AS）是糖尿病的并发症之一，与许多代谢因素有关。本研究旨在探讨 25-羟维生素 D（25（OH）D）与 2 型糖尿病（T2DM）患者 AS 的关系。
方法
我们从上海第十人民医院内分泌科鉴定了 1335 名糖尿病患者。最终，603 名 T2DM 患者纳入本研究。他们被分为两组：AS 组（baPWV≥15500cm/s）和对照组（baPWV<1550cm/s）。
结果
（1）与对照组相比，AS 组的心率（HR）和收缩压（SBP）较高，而体重和体重指数（BMI）较小（均 P<0.05）。（2）与无 AS 患者相比，AS 患者的 25（OH）D 水平较低，25（OH）D 缺乏率较高（42±16 比 45±17mol/l，68%比 64%，均 P<0.05）。（3）baPWV 与 25（OH）D 呈负相关（r=-0.12，P=0.004），与年龄、糖尿病病程、HR、SBP、低密度脂蛋白胆固醇呈正相关，与体重和 BMI 呈负相关（均 P<0.05）。（4）多元线性回归显示，25（OH）D 是 baPWV 的负影响因素（β=-2.2，P=0.01）。Logistic 回归显示，年龄和 SBP 是 AS 的危险因素（OR：1.07，95%CI：1.05-1.10，P<0.001；OR：1.03，95%CI：1.02-1.04，P<0.001），而 25（OH）D 是 AS 的保护因素（OR：0.987，95%CI：0.976-0.998，P=0.024）。
结论
患有 AS 的 T2DM 患者 25（OH）D 水平较低，25（OH）D 缺乏率较高。baPWV 评估的 25（OH）D 与 AS 呈负相关。
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