Samadian Mohammad, Gholipour Mahdi, Hajiesmaeili Mohammadreza, Taheri Mohammad, Ghafouri-Fard Soudeh
Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Front Aging Neurosci. 2021 Mar 15;13:641080. doi: 10.3389/fnagi.2021.641080. eCollection 2021.
Alzheimer's disease (AD) is an irrevocable neurodegenerative condition characterized by the presence of senile plaques comprising amassed β-amyloid peptides (Aβ) and neurofibrillary tangles mainly comprising extremely phosphorylated Tau proteins. Recent studies have emphasized the role of microRNAs (miRNAs) in the development of AD. A number of miRNAs, namely, miR-200a-3p, miR-195, miR-338-5p, miR-34a-5p, miR-125b-5p, miR-132, miR-384, miR-339-5p, miR-135b, miR-425-5p, and miR-339-5p, have been shown to participate in the development of AD through interacting with BACE1. Other miRNAs might affect the inflammatory responses in the course of AD. Aberrant expression of several miRNAs in the plasma samples of AD subjects has been shown to have the aptitude for differentiation of AD subjects from healthy subjects. Finally, a number of AD-modifying agents affect miRNA profile in cell cultures or animal models. We have performed a comprehensive search and summarized the obtained data about the function of miRNAs in AD in the current review article.
阿尔茨海默病（AD）是一种不可逆转的神经退行性疾病，其特征是存在由聚集的β-淀粉样肽（Aβ）组成的老年斑和主要由高度磷酸化的 Tau 蛋白组成的神经原纤维缠结。最近的研究强调了微小 RNA（miRNA）在 AD 发展中的作用。一些 miRNA，即 miR-200a-3p、miR-195、miR-338-5p、miR-34a-5p、miR-125b-5p、miR-132、miR-384、miR-339-5p、miR-135b、miR-425-5p 和 miR-339-5p，已被证明通过与β-分泌酶 1（BACE1）相互作用参与 AD 的发展。其他 miRNA 可能会影响 AD 病程中的炎症反应。AD 患者血浆样本中几种 miRNA 的异常表达已被证明有能力区分 AD 患者和健康受试者。最后，一些 AD 修饰剂会影响细胞培养物或动物模型中的 miRNA 谱。在当前的综述文章中，我们进行了全面的搜索并总结了关于 miRNA 在 AD 中的功能的所得数据。
Zotero 插件